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Optimal control of intervention strategies in malaria-tuberculosis co-infection with relapse 被引量:3

Optimal control of intervention strategies in malaria-tuberculosis co-infection with relapse
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摘要 A model which incorporates some of the basic epidemiological features of the co- dynamics of malaria and tuberculosis (TB) is formulated and the effectiveness of current intervention strategies of these two diseases is analyzed. The malaria-only and TB-only models are considered first. Global stability disease-free steady states of the two sub- models does not hold due to the co-existence of stable disease-free with stable endemic equilibria, a phenomenon known as backward bifurcation. The dynamics of the dual malari^TB model with intervention strategies are also analyzed. Numerical simulations of the malaria-TB model are carried out to determine whether the two diseases can co- exist. Lastly, sensitivity analysis on key parameters that drive the disease dynamics is performed in order to identify their relative importance to disease transmission.
出处 《International Journal of Biomathematics》 SCIE 2018年第2期27-64,共38页 生物数学学报(英文版)
关键词 TUBERCULOSIS MALARIA CO-INFECTION intervention strategies optimal controltheory. 肺结核 疟疾 核合作 疾病传播 控制 感染 恶化 动力学
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