RF、ASO、CRP、ACCP联合检测类风湿性关节炎的临床意义

Clinical significance of combined detection of RF, ASO, CRP and ACCP in patients with rheumatoid arthritis

目的探讨血清类风湿因子(RF)、抗链球菌溶血素"O"(ASO)、C反应蛋白(CRP)、抗环瓜氨酸肽抗体(ACCP)联合检测类风湿性关节炎(RA)的临床意义。方法选择46例健康人群为对照组,同期在我院就诊的46例非RA患者为非RA组,50例RA患者作为RA组。检测并比较三组血清RF、ASO、CRP及ACCP水平。结果 RA组患者的血清RF、ASO、CRP及ACCP水平均显著高于对照组及非RA组(P<0.05);非RA组的血清RF、ACCP及ASO水平显著高于对照组(P<0.05),非RA组与对照组的CRP水平比较,差异不显著(P>0.05)。RF、ACCP、CRP及ASO四种指标联合检测的灵敏度和特异度显著高于单项检测(P<0.05)。结论联合检测血清中RF、ASO、CRP及ACCP水平具有更高的灵敏度和特异度,利于RA患者的病情诊断,减少误诊、漏诊,对于RA病情的监测有重要临床价值。

Objective To investigate the clinical significance of combined detection of rheumatoid factor （RF）, anti- streptococcus hemolysin （ASO）, c-reactive protein （CRP） and anticyclopanine peptide antibody （ACCP） in patients with rheumatoid arthritis （RA）. Methods A total of 46 healthy people were selected as the control group, and 46 cases non- RA patients in our hospital in the same period were selected as the non-RA group; while 50 patients with RA in our hospital were selected as the RA group. The levels of serum RF, ACCP, ASO and CRP in all objects of study were de- tected and compared. Results The levels of serum RF, ACCP, ASO and CRP in the RA group were significantly higher than those in the non-RA group and the control group （P〈0.05）. The levels of serum RF, ACCP and ASO in the non-RA group were significantly higher than those in the control group （P〈0.05）; while the level of CRP in the non-RA group and the control group were not significantly different （P〉0.05）. The sensitivity and specificity of the combination of serum RF, ACCP, ASO and CRP were higher than those of the single detection （P〈0.05）. Conclusion Combined detection of the levels of serum RF, ACCP, ASO and CRP has higher sensitivity and specificity, it is good for the diagnosis of RA patients, and can reduce the misdiagnosis and missed diagnosis, which has important clinical value for the RA condition monitoring.