内镜止血联合奥美拉唑在消化道出血患者中的疗效观察及对凝血因子的影响研究

Effect of Endoscopic Hemostasis Combined with Omeprazole in Patients with Gastrointestinal Bleeding and its Effect on Coagulation Factors

目的:探讨内镜止血联合奥美拉唑在消化道出血患者中的疗效及对凝血因子的影响。方法:选取2016年1月—2017年6月我院收治的消化道出血患者78例,应用数字表法将患者随机分为对照组与研究组,对照组运用内镜止血进行治疗,研究组在对照组的基础上联合奥美拉唑进行治疗,比较2组患者治疗后止血成功率,随访并比较2个月再出血发生率、4个月再出血发生率和6个月再出血发生率,生活质量评分,临床治疗效果,止血时间、输血量、住院时间以及比较2组患者治疗前后凝血功能变化。结果:研究组患者的止血成功率高于对照组(P<0.05);2个月再出血发生率、4个月再出血发生率和6个月再出血发生率均低于对照组(P<0.05);研究组患者的生活质量评分高于对照组(P<0.05);研究组患者的临床治疗效果优于对照组(P<0.05);研究组患者的止血时间、输血量、住院时间等均低于对照组(P<0.05);治疗前2组患者的PT、APTT、D-D、PLT、FIB因子的凝血功能没有明显的差异(P>0.05),治疗后研究组患者的PT、APTT、D-D、FIB因子凝血功能低于对照组(P<0.05),PLT因子的凝血功能高于对照组(P<0.05)。结论:在治疗消化道出血患者的过程中,内镜止血联合奥美拉唑的治疗效果更好,临床上应当进一步推广应用。

Objective： To investigate the efficacy of endoscopic hemostasis combined with omeprazole in patients with gastrointestinal bleeding and its effect on coagulation factors. Methods： 78 cases of patients with gastrointestinal bleeding in our hospital from January 2016-June 2017 were randomly divided into control group and research group. The control group use endoscopic hemostatic treatment, the research group combined omeprazole treatment on the basis of endoscopic hemostatic treatment. The stop bleeding rate and the incidence of bleeding follow 2, 4,6 months and the quality of life score, clinical effect, the bleeding time, blood transfusion amount, and length of hospital stay were compared between the two groups of patients before and after treatment. Results： The success rate of hemostasis in the group was higher than that in the control group（P〈0.05）. The incidence of bleeding in 2 months, the incidence of re-bleeding in 4 months and the incidence of re-bleeding in 6 months were all lower than that in the control group（P〈0.05）. The quality of life of the patients in the study group was higher than that in the control group（P〈0.05）. The clinical treatment effect of the group was better than that of the control group（P〈0.05）. The hemostasis time, blood transfusion volume and hospitalization time of the patients in the study group were lower than that in the control group（P〈0.05）. Two groups of patients before treatment of PT, APTT, D-D, PLT and FIB factor of blood coagulation function had no obvious difference（P〈0.05）. PT, APTT, D-D, FIB factor coagulation function in treatment group patients is lower than the control group（P〈0.05）, and the affecting factors of PLT coagulant function is higher than the control group（P〈0.05）. Conclusion： Endoscopic hemostasis combined with omeprazole in the treatment of patients with gastrointestinal hemorrhage is better and should be further popularized in clinic.