银杏达莫联合丹参注射液治疗冠心病心绞痛临床研究

Clinical research of Ginkgo Leaf Extract and Dipyridamole Injection combined with Salvia Miltiorrhiza Injection in the treatment of angina pectoris of coronary heart disease

目的研究银杏达莫联合丹参注射液治疗冠心病心绞痛的临床疗效。方法 90例冠心病心绞痛患者,根据治疗方案不同分为对照组和观察组,各45例。对照组采取丹参注射液治疗,观察组在对照组基础上联合银杏达莫注射液治疗。观察比较两组血液流变学指标、心绞痛发作持续时间及发作次数以及临床疗效。结果治疗前,两组患者红细胞比容、血小板粘附率、全血低切粘度、全血高切粘度比较,差异无统计学意义(P>0.05);治疗后,观察组患者红细胞比容、血小板粘附率、全血低切粘度、全血高切粘度低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者心绞痛发作持续时间、发作次数比较,差异具无统计学意义(P>0.05);治疗后,观察组患者心绞痛发作持续时间短于对照组,发作次数少于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率为95.56%,显著高于对照组的80.00%,差异有统计学意义(P<0.05)。两组均未发生不良反应。结论针对冠心病心绞痛患者采用银杏达莫联合丹参注射液治疗的临床疗效非常显著,既可有效降低患者血粘度,又能改善其各种临床症状,且无不良反应,具有较高的安全性,值得临床应用推广。

Objective To research the clinical effect of Ginkgo Leaf Extract and Dipyridamole Injection combined with Salvia Miltiorrhiza Injection in the treatment of angina pectoris of coronary heart disease. Methods A total of 90 patients with angina pectoris of coronary heart disease were divided into control group and observation group according to the different treatment regimens, 45 cases in each group. The control group was treated with Salvia Miltiorrhiza Injection, the observation group was treated with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of control group. The hemorheological indexes, duration of angina pectoris attack, frequency of attack and clinical efficacy were observed and compared between the two groups. Results Before treatment, there were no significant differences in the hematocrit, platelet adhesion rate, whole blood low shear viscosity and whole blood high shear viscosity between the two groups（P〉0.05）. After treatment, the hematocrit, platelet adhesion rate, whole blood low shear viscosity and whole blood high shear viscosity of the observation group were significantly lower than those of the control group, the differences were statistically significant（P〈0.05）. Before treatment, there were no significant differences in the duration and frequency of angina pectoris attack between the two groups（P〉0.05）. After treatment, the duration of angina pectoris attack in the observation group was significantly shorter than that in the control group, and the frequency of attacks was significantly less than that in the control group, the differences were statistically significant（P〈0.05）. The total effective rate of the observation group was 95.56%, which was significantly higher than 80.00% of the control group, the difference was statistically significant（P〈0.05）. No adverse reactions occurred in the two groups. Conclusion The clinical effect of Ginkgo Leaf Extract and Dipyridamole Injection combined with Salvia Miltiorrhiza Injection in the treatment of angina pectoris of coronary heart disease is very significant, it can effectively reduce the blood viscosity and improve various clinical symptoms and without adverse reactions. It is safe, worthy of clinical application and promotion.