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Early mortality and safety after transcatheter aortic valve replacement using the SAPIEN 3 in nonagenarians 被引量:2

Early mortality and safety after transcatheter aortic valve replacement using the SAPIEN 3 in nonagenarians
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摘要 Background Transcatheter aortic valve replacement (TAVR) has been performed for many elderly patients with severe aortic stenosis (AS). The SAPIEN 3 is one of the latest balloon-expandable prosthesis. This study aimed to investigate the early clinical outcomes after TAVR using the SAPIEN 3 in nonagenarians. Methods A total of 97 consecutive patients underwent TAVR for severe AS between De- cember 2015 and December 2016. Of these, 85 consecutive patients who underwent TAVR using the SAPIEN 3 were included. According to the age, patients were classified into age 〉 90 years group (17 patients) or age 〈 90 years group (68 patients). The clinical outcomes in- cluding all-cause mortality and composite endpoint of early safety at 30 days were evaluated. Results The Society of Thoracic Surgeons score in age 〉 90 years group was higher than age 〈 90 years group (12.3 ±6.1% vs. 8.5 ± 5.1%, P 〈 0.01). There was no significant difference in 30-day mortality between the two groups. However, the life-threatening bleeding and major vascular complications in age 〉 90 years group were greater than age 〈 90 years group (11.8% vs. 1.5%, P = 0.04 and 11.8% vs. 1.5%, P = 0.04, respectively). The composite endpoint of early safety at 30 days was similar between the two groups. Multivariate logistic regression analysis showed that prior myocardial infarction was an independent predictor of the composite endpoint of early safety (odds ratio: 4.76, 95% confidence interval: 1.02-22.21, P = 0.047). Conclusions The early mortality and safety after TAVR using the SAPIEN 3 in nonagenarians were similar and acceptable despite of higher operative risk.
出处 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第6期387-393,共7页 老年心脏病学杂志(英文版)
关键词 NONAGENARIANS SAPIEN 3 Transcatheter aortic valve replacement 大动脉 安全 死亡 阀门 回归分析 年龄 修复术 端点
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