探讨阿托伐他汀联合抗血小板药治疗对脑血栓的效果、血小板参数及后遗症发生率的影响

Influence discussion of Atorvastatin combined with antiplatelet drugs on the effect of cerebral thrombosis, platelet parameters and incidence of sequelae

目的分析阿托伐他汀联合抗血小板药治疗对脑血栓的效果、血小板参数及后遗症发生率的影响。方法 120例脑血栓患者,随机分为对照组和观察组,各60例。对照组采用抗血小板药治疗,观察组采用阿托伐他汀联合抗血小板药治疗。比较两组治疗效果、治疗前后血小板参数及后遗症发生情况。结果观察组总有效率为93.33%,显著高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组血小板计数、血小板黏附率、平均血小板体积均低于对照组,差异有统计学意义(P<0.05)。对照组出现语言障碍6例、肢体功能障碍8例、静脉血栓4例,后遗症发生率为30.00%(18/60);观察组出现语言障碍3例、肢体功能障碍4例,后遗症发生率为11.67%(7/60);两组后遗症发生率比较,差异有统计学意义(P<0.05)。结论阿托伐他汀联合抗血小板药治疗脑血栓效果确切,可显著改善患者血小板指标,降低后遗症发生率,值得临床推广。

Objective To analyze the influence of Atorvastatin combined with antiplatelet drugs on the effect of cerebral thrombosis, platelet parameters and incidence of sequelae. Methods A total of 120 patients with cerebral thrombosis were randomly divided into control group and observation group, 60 cases in each group. The control group was treated with antiplatelet drugs, the observation group was treated with the combination of Atorvastatin and antiplatelet drugs. The therapeutic effects, platelet parameters before and after treatment, occurrence of sequelae between the two groups were compared. Results The total effective rate of the observation group was 93.33%, which was significantly higher than 80.00% of the control group, the difference was statistically significant （P〈O.05）. After treatment, the platelet count, platelet adhesion rate and mean platelet volume of the observation group were significantly lower than those of the control group, the differences were statistically significant （P〈O.05）. There were 6 cases of language disorder, 8 cases of limb dysfunction and 4 cases of venous thrombosis in the control group, the incidence of sequelae was 30.00% （18/60）. There were 3 cases of language disorder and 4 cases of limb dysfunction in the observation group, the incidence of sequelae was 11.67% （7/60）, the difference was statistically significant in the incidence of sequelae betwean.the two groups （P〈O.05）. Conclusion The application of Atorvastatin combined with antiplatelet drugs in the treatment of cerebral thrombosis is effective, it can significantly improve the platelet indexes, reduce the incidence of sequelae, is worthy of clinical promotion.