地龙拮抗左旋亚硝基精氨酸的致卒中作用

The Effect of Lumbricus on Stroke Induced by L-Nitro-Arginine

地龙是祛风平痉活血中药,具降低血压,减少脑卒中危险因素发生的作用。本实验观察地龙对一氧化氮(NO)缺乏时,自发性高血压大鼠脑卒中的发生率。结果发现地龙通过增加血管内膜一氧化氮合成酶活性[即左旋亚硝基精氨酸(L-NNA)]致 NO 缺乏组是(8.63±2.80)pmol·μg·pro^(-1)·min^(-1),同时加饲地龙组上升至(10.87±2.90)pmol·μg·pro^(-1)·min^(-1),增加胸主动脉及供应脑颈内动脉一氧化氮基础释放和激动剂刺激释放(P<0.05),对防治脑卒中有益。本研究阐述了地龙防治脑卒中机制,为今后开发利用地龙提供理论依据。

A Chinese medicine with function of expelling Wind,relieving spasm and promoting blood circulation was reported to be able to decrease the blood pressure and dangerousness of stroke.In the present study,the effect of Lumbricus on the incidence of stroke in spontaneously hypertensive rat induced by lack of L-nitro-arginine(L-NA)was observed.The results indicated that Lumbricus decreased the incidence of stroke(5/10 vs 10/14),alleviated the stroke degree,and has benefical effects on pre- venting and treating stroke by increasing the activity of nitric oxide(NO)synthetase in aortic endothelium(8.63±2.80 pmol/μg pro·min in L-NA group and 10.87±2.90 pmol/μg pro·min in Lumbricus group),increasing basal content of NO release of stimulant(P&lt;0.05).These results illustrated the new mechanism of Lumbricus on protecting and treating the stroke,and sup- plied the theoretieal basis for the development and use of Lumbrieus.