卡前列甲酯栓与缩宫素联合预防瘢痕子宫产后出血的效果分析

Effect analysis of carboprost methylate suppositories combined with oxytocin in prevention of scarred uterus postpartum hemorrhage

目的探讨卡前列甲酯栓与缩宫素联合预防瘢痕子宫产后出血的效果。方法 180例瘢痕子宫患者,随机分为研究组与对照组,各90例。对照组应用20 U缩宫素预防子宫产后出血,研究组应用10 U缩宫素+1 mg卡前列甲酯栓预防子宫产后出血。观察两组产后2 h与24 h出血量、产后出血率及药物不良反应情况。结果研究组产后2 h、24 h出血量为(146.2±30.5)、(252.5±50.5)ml均低于对照组的(242.5±40.5)、(365.5±60.5)ml,差异有统计学意义(P<0.05)。研究组产后出血的发生率为0,低于对照组的6.67%,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率对比差异无统计学意义(P>0.05)。结论卡前列甲酯栓与缩宫素联合预防瘢痕子宫产后效果显著,适于临床应用。

Objective To explore the effect of carboprost methylate suppositories combined with oxytocin in prevention of scarred uterus postpartum hemorrhage. Methods A total of 180 scarred uterus patients were randomly divided into research group and control group, with 90 cases in each group. The control group received 20 U oxytocin for prevention of uterus postpartum hemorrhage, and the research group received 10 oxytocin +1 mg carboprost methylate suppositories for prevention of uterus postpartum hemorrhage. Observation were made on bleeding volume, postpartum bleeding rate and adverse drug reactions at postpartum 2 and 24 h in two groups. Results The research group had less bleeding volume at postpartum 2 and 24 h as (146.2±30.5) and (252.5±50.5) ml than (242.5±40.5) and (365.5±60.5) ml in the control group, and their difference had statistical significance (P<0.05). The research group had lower postpartum bleeding rate as 0 than 6.67% in the control group, and the difference had statistical significance (P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions in the course of treatment (P>0.05). Conclusion Combination of carboprost methylate suppositories and oxytocin shows significant effect in prevention of scarred uterus postpartum hemorrhage, and it is suitable for clinical application.