主动干预治疗学龄儿童单纯性肥胖症的临床研究

Clinical Research on Active Intervention in Treatment of Simple Obesity of School-age Children

目的探讨针对学龄儿童中患单纯性肥胖症,应用主动干预治疗的临床效果。方法 2015年3月—2016年12月,方便选取该辖区小学中120例年龄为6~12岁的患单纯性肥胖症的学龄儿童为研究对象,随机分为观察组与对照组各60例,对照组不给予干预措施,观察组给予主动干预治疗,比较两组对象治疗前后的体重、皮脂厚度及多项生化指标,计算观察组的治疗有效率。结果在3个月后,对照组的皮脂厚度为(33.3±2.1)mm,体重为(35.5±2.2)kg,高于观察组的(26.2±2.0)mm,(31.7±2.5)kg,差异有统计学意义(P<0.05)。观察组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏C-反应蛋白(hs-CRP)水平均明显低于对照组(P<0.05);而高密度脂蛋白胆固醇(HDL-C)平均明显高于对照组,差异有统计学意义(P<0.05);观察组的治疗有效率为93.3%。结论在患单纯性肥胖症的学龄儿童中hsCRP的检测可能成为肥胖儿童的重要预测因子,作为单纯性肥胖症患儿的治疗新靶点成为可能。应用主动干预治疗患单纯性肥胖症的学龄儿童效果显著,建议普及使用。

Objective To study the clinical effect of active intervention in treatment of simple obesity of school-age children.Methods 120 cases of school-age children with simple obesity in the primary from March 2015 to December 2016 were convenient selected as the research objects and randomly divided into two groups with 60 cases in each,the control group did not adopt the intervention measures,while the observation group were given the intervention treatment,and the weight,skin fat thickness and multiple biochemical indicators were compared between the two groups,and the treatment effective rate in the observation group was calculated.Results After three months,the skin fact thickness,weight in the control group were much higher than those in the observation group,[(33.3±2.1)mm,(35.5±2.2)kg vs(26.2±2.0)mm,(31.7±2.5)kg],and the differences were statistically significant(P<0.05),and the TC,TG,LDL-C,hs-CRP levels in the observation group were obviously lower than those in the control group(P<0.05),and the HDL-C level was obviously higher than that in the control group,and the difference was statistically significant(P<0.05),and the treatment effective rate in the observation group was 93.3%.Conclusion The hs-CRP test in school-age children with simple obesity can be an important predication factor of obesity children,which is likely to be a treatment target of children with simple obesity,and the effect of active intervention in treatment of simple obesity of school-age children is obvious,and it is suggested to be widely used.