痛利舒颗粒治疗急性痛风性关节炎的实验研究

Experimental study on treating acute gouty arthritis with Tonglishu Granule

通过对痛利舒颗粒的相关药理学研究,评价其对急性痛风性关节炎的治疗作用。建立尿酸钠致急性痛风性关节炎大鼠模型,给予痛利舒颗粒3. 24、6. 48、12. 96 g/kg,考察对踝关节肿胀程度的改善情况;采用热板法测定小鼠痛阈值,给予痛利舒颗粒4. 68、9. 36、18. 72 g/kg,评价其镇痛作用效果;建立巴豆油致小鼠耳廓肿胀模型,给予痛利舒颗粒4. 68、9.36、18. 72 g/kg,观察其抗炎作用的效果。结果显示,痛利舒颗粒可以改善大鼠踝关节肿胀程度和降低炎症因子TNF-α、IL-6含量,提高热板法所测的小鼠的痛阈值,具有一定的镇痛作用,亦对巴豆油所致小鼠耳廓肿胀有一定的抗炎作用。

Through pharmacological study on Tonglishu Granule,its therapeutic effects on acute gouty arthritis were evaluated. A rat model of acute gouty arthritis induced by sodiumurate was established. Tonglishu Granules were given3. 24,6. 48,12. 96 g/kg respectively to investigate the improvement of ankle swelling degree; The pain threshold of mice was determined by hot plate method,and Tonglishu Granules were given 4. 68,9. 36,18. 72 g/kg to evaluate the painrelieving effect; To establish a model for auricle swelling in mice induced by croton oil,Tonglishu Granules were given 4.68,9. 36,18. 72 g/kg to observe its anti-inflammatory effect. The results showed that Tonglishu Granule could improve the degree of ankle joint swelling in rats and reduce the levels of inflammatory factors TNF-α and IL-6,and improve the pain threshold of mice measured by hot plate method,which had certain analgesic effect. Tonglishu Granule also had certain anti-inflammatory effect on croton oil-induced ear swelling in mice.