IFITM3基因遗传变异rs12252与流感易感性及严重程度的Meta分析

Association of Interferon-inducible Transmembrane Protein 3 Genetic Variant rs12252 with Influenza Susceptibility and Severity:A Meta-analysis

目的综合评价干扰素诱导跨膜蛋白3(IFITM3)基因遗传变异rs12252对流感发病及严重程度的影响。方法全面检索相关中外文数据库,收集2018年6月前发表的有关rs12252遗传变异与流感易感性及严重程度的人群关联研究。使用Stata 14.0软件进行统计分析。结果最终11项研究经筛选纳入分析。结果显示rs12252T>C遗传变异显著增加流感发病风险。其显性模型、隐性模型、等位基因模型下的相对危险度(OR)及95%置信区间(95%CI)分别为1.64(1.22～2.22)、2.76(1.71～4.43)和1.69(1.32～2.18)。同时,该遗传变异还与流感的严重程度显著相关。其显性模型、隐性模型、等位基因模型下的OR及95%CI分别为1.91(1.08～3.39)、2.49(1.14～5.42)和1.85(1.23～2.79)。结论 rs12252T>C遗传变异与流感发病和重症化风险增加显著相关。

Objective To comprehensively evaluate the association of the interferon-inducible transmembrane protein3(IFITM3)genetic variant rs12252with influenza susceptibility and severity.Methods Relevant studies published before June1,2018were retrieved from PubMed,web of science,OVID,CNKI,CBM and Wanfang databases.Data from these studies were analyzed using Stata14.0.Results A total of11studies were finally included in the meta-analysis.Our results showed that rs12252T>C alteration increased the risk of influenza significantly.The odds ratio(OR)and95%confidence interval(95%CI)were1.69(1.32-2.18),1.64(1.22-2.22)and2.76(1.71-4.43)under the allelic,dominant and recessive models,respectively.Moreover,rs12252T>C was associated with severity of influenza,and the OR and95%CI of three models above were1.85(1.23-2.79),1.91(1.08-3.39)and2.49(1.14-5.42),respectively.Conclusion Our meta-analysis suggests that IFITM3rs12252T>C genetic variant is significantly associated with increased risk and severity of influenza.