木荷树皮乙醇提取物抗炎镇痛作用研究

Anti-inflammatory and Analgesia Effects of Alcohol Extract from Barks of Shimasuperba

分别采用醋酸扭体法、二甲苯致小鼠耳廓肿胀法、热板致痛法观察木荷Shima superba树皮乙醇提取物对小鼠的镇痛及抗炎作用。结果表明:1)木荷树皮乙醇提取物能够有效地抑制醋酸引起的小鼠镇痛扭体反应。其200mg·kg-1处理组、400mg·kg-1处理组、800mg·kg-1处理组对小鼠的镇痛率分别为37.9%、52.2%和66.7%,阿司匹林200mg·kg-1处理组的镇痛率为37.4%。2)木荷树皮乙醇提取物能够降低二甲苯引起的小鼠耳廓肿胀。其200 mg·kg-1处理组、400mg·kg-1处理组、800 mg·kg-1处理组对小鼠耳廓肿胀的抑制率分别为35.1%、56.8%和69.3%,阿司匹林200mg·kg-1处理组的抑制率为54.9%。3)木荷树皮乙醇提取物能够提高热板致痛的小鼠痛阈值。其200mg·kg-1处理组、400mg·kg-1处理组、800mg·kg-1处理组药后60min,小鼠痛阈提高率分别为50.1%、63.3%和78.3%,阿司匹林200mg·kg-1处理组的痛阈提高率为63.6%。可见木荷树皮乙醇提取物有明显的抗炎消肿、镇痛的作用。

Anti-inflammatory and analgesia effects were observed by methods of acetic acid writhing,ear edema induced by xylene and hot-plate respectively.The results showed that the alcohol extracts from barks of Shima superba could significantly inhibite the number of writhing induced by acetic acid.The rates of anti-inflammatory and analgesia effects of 3 groups which treated mice with extracts from barks of S.superba(200mg·kg^-1,400mg·kg^-1,800mg·kg^-1)were 37.9%,52.2% and 66.7%.The rate of anti-inflammatory and analgesia effects of aspirin groups(200mg·kg^-1)was 37.4%.The alcohol extracts from barks of S.superba could reduce the ear edema induced by xylene.The rates of inhibition ear edema of 3 groups which treated mice with extracts from barks of S.superba(200mg·kg^-1,400mg·kg^-1,800mg·kg^-1)were 35.1%,56.8%and 69.3%.The rate of inhibition ear edema of aspirin groups(200mg·kg^-1)was54.9%.The alcohol extracts from barks of S.superba could significantly enhance the pain threshold on hot-plate in mice.The rates of enhance the pain threshold of3groups which treated mice with extracts from barks of S.superba(200mg·kg^-1,400mg·kg^-1,800mg·kg^-1)when 60min after the last administration were 50.1%,63.3% and 78.3%.The rate of enhance the pain threshold of aspirin groups(200mg·kg^-1)was 63.6%.So the alcohol extracts from barks of S.superba have obvious effect on anti-inflammatory and analgesia.