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新型P2Y12受体拮抗剂及精准抗血小板在冠心病治疗中的研究进展

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摘要 冠心病是临床上十分常见的心血管疾病,也是导致现代老年人群急性死亡的主要原因之一。血小板活化和聚集是导致冠心病发生、发展的重要因素及参与因子,而在对这种病症进行治疗时,近年来的P2Y12受体拮抗剂和精准抗血小板治疗有了进一步研究。但值得注意的是,临床常用的氯比格雷属于一种ADP受体拮抗剂,无法起到精准抗血小板的效果,反而会增加支架内血栓形成的风险。而近年来的新型P2Y12受体拮抗剂,在临床上已经获得了一定的研究和应用,所以本文中探究了P2Y12受体拮抗剂以及精准抗血小板应用于冠心病治疗中的研究进展,旨在为我国冠心病控制提供帮助和参考。
作者 王保娟
出处 《医学食疗与健康》 2018年第12期290-290,共1页 Medical Diet and Health
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  • 1梁文生,姜德谦,刘启明.中青年急性心肌梗死患者的生活方式及冠状动脉病变特征分析[J].中国心血管杂志,2007,12(2):118-120. 被引量:28
  • 2Davies MJ. The pathophysiology of acute coronary syndromes[J]. Heart,2000,83:361 - 366.
  • 3Steinhubi SR_, Berger PB, Tift Mann Ⅲ J, et al. Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention A Randomized Controlled Trial[J]. JAMA, 2002, 288(19):2411-2420.
  • 4Han YL, Li Y, Wang S, et al. Cilostazol in addition tc aspirin and clopidogrel improves long-term outcomes at~eJ percutaneous coronary intervention in patients with acute coronary syndromes: A randomized, controlled study[]] American Heart Journal, 2009,157(4), 733-739.
  • 5Matetzky S, Shenkrnan B, Guetta V, et al. Clopidogrel Resistance Is Associated With Increased Risk of Recurrent Atherothrombofic Events in Patients With Acute Myocardial ~on0]. Circulation, 2004, 109: 3171-3175.
  • 6Price MJ, Berger PB, Teirstein PS, et al. Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention: The GRAVITAS Randomized Trial[J]. JAMA, 2011, 305(11):1097-1105.
  • 7Brandt JT, Close SL, Iturria SJ,et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel[l]. Journal of Thrombosis and Haemostasis, 2007, 12(5): 2429 - 2436.
  • 8Gurbel PA, Bliden KP, Logan DK, et al. The Influence of Smoking Status on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel: The PARADOX Study[J]. J Am Coll Cardiol, 2013,62(6):505-512.
  • 9Porten BR, Strauss CE, Ccarberich RF, et al. Comparative Effectiveness and Clinical Outcomes of Clopidogrel versus Prasugrel in Acute Coronary Syndrome Patients with Diabetes MeUitus Undergoing Percutaneous Coronary Intervention[J]. Circulation: Cardiovascular Quality and Outcomes, 2014, 7: A133.
  • 10Cannon CP, Harrington R.A, James S, et al. Comparison of ticagrelor with clopidogxel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study[J]. The Lancet,2010, 9711(375) : 283 - 293.

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