川芎嗪结构修饰产物Liguzinediol对阿霉素致慢性心力衰竭模型大鼠血流动力学的影响

Effects of Ligustrazine Structural Modification Product Liguzinediol on Hemodynamics of Chronic Heart Failure Model Rats Induced by Adriamycin

目的:探讨川芎嗪结构修饰产物Liguzinediol对阿霉素诱导的慢性心力衰竭(CHF)模型大鼠血流动力学的影响。方法:取SD大鼠腹腔注射2 mg/kg阿霉素复制CHF模型,将造模成功的大鼠采用随机数字表法分为生理盐水组、阳性对照组(去乙酰毛花苷注射液,0.022 5 mg/kg)和Liguzinediol低、中、高剂量组(5、10、20 mg/kg),每组8只,另取8只正常大鼠作为空白对照组(生理盐水)。各组大鼠单次静脉注射相应药物后,通过多道生理记录仪左心室插管记录左心室收缩内压(LVSP)、左心室最大压力上升/下降速度(±dp/dt_(max))、收缩压(SP)、舒张压(DP)、心率(HR)等血流动力学指标,记录时间分别为给药后1、5、10、20、40、60、90、120 min。结果:与空白对照组比较,生理盐水组大鼠的LVSP、+dp/dt_(max)、│-dp/dt_(max)│、SP、HR和给药后120 min的DP均明显降低(P<0.05)。与生理盐水组比较,Liguzinediol低剂量组大鼠给药后5～60 min的LVSP、40～90 min的+dp/dt_(max)、10～40 min的SP均明显升高(P<0.05或P<0.01);Liguzinediol中剂量组大鼠给药后5～90 min的LVSP、10～60 min的SP、10～60 min(20 min除外)的DP均明显升高(P<0.05或P<0.01);Liguzinediol高剂量组大鼠给药后1～120 min的LVSP、5～90 min的+dp/dt_(max)、5～60 min的│-dp/dt_(max)│和SP、40～60 min的DP均明显升高(P<0.05或P<0.01)。结论:单次静脉注射Liguzinediol能显著增强CHF模型大鼠的心肌收缩功能,进而控制或缓解其CHF。

OBJECTIVE:To investigate the effects of ligustrazine structural modification product Liguzinediol on hemodynamics in chronic heart failure(CHF)model rats induced by adriamycin.METHODS:SD rats were given intraperitoneal injection of adriamycin(2 mg/kg)to induce CHF model.Model rats were randomly divided into normal saline group,positive control group(Deacetyl tricyanidin injection,0.022 5 mg/kg)and Liguzinediol low-dose,medium-dose and high-dose groups(5,10,20 mg/kg),with 8 rats in each group.Other 8 normal rats were selected as blank control group(normal saline).Each group was given relevant medicine intravenously.The left ventricular systolic pressure(LVSP),maximal rate of rise or drop of left ventricular(±dp/dtmax),systolic pressure(SP),diastolic pressure(DP),heart rate(HR)and other hemodynamic indexes were recorded by multichannel physiological recorder at 1,5,10,20,40,60,90,120 min after medication.RESULTS:Compared with blank control group,LVSP,+dp/dtmax,│-dp/dtmax│,SP,HR and DP at 120 min after medication of normal saline group were decreased significantly(P<0.05).Compared with normal saline group,LVSP at 5-60 min after medication,+dp/dtmax at 40-90 min after medication,SP at 10-40 min after medication were increased significantly in Liguzinediol low-dose group(P<0.05 or P<0.01).LVSP at 5-90 min after medication,SP at 10-60 min after medication,DP at 10-60 min(except for 20 min)after medication were increased significantly in Liguzinediol medium-dose group(P<0.05 or P<0.01).LVSP at 1-120 min after medication,+dp/dtmax at 5-90 min after medication,│-dp/dtmax│,and SP at 5-60 min after medication,DP at 40-60 min after medication were increased significantly in Liguzinediol high-dose group(P<0.05 or P<0.01).CONCLUSIONS:Single intravenous injection of Liguzinediol can significantly enhance ventricular systolic function of CHF model rats so as to control or relieve CHF.