大株红景天注射液治疗急性复发性脑梗死的临床研究

Clinical study on Dazhu Hongjingtian Injection for treatment of acute recurrent cerebral infarction

目的观察大株红景天注射液治疗急性复发性脑梗死的疗效。方法将100例急性复发性脑梗死患者随机分为对照组和治疗组,各50例。两组患者均采用常规治疗,对照组在此基础上口服阿司匹林肠溶片,治疗组在对照组治疗方案基础上给予大株红景天注射液静脉滴注,均治疗2周。比较两组血流动力学指标变化、血浆血栓调节蛋白(TM)、组织纤溶酶原激活物抑制物(PAI)、组织纤溶酶原激活物(t-PA)、D-二聚体(D-D)、血管内皮生长因子(VEGF)水平及临床疗效。结果治疗后,治疗组全血高切黏度、血浆高切黏度及TM、PAI、D-D均低于对照组,t-PA、VEGF均高于对照组(均P <0. 05)。治疗组疗效优于对照组(P <0. 05)。结论在常规治疗基础上联合应用大株红景天注射液治疗急性复发性脑梗死疗效确切,上调患者体内VEGF水平可能是其疗效途径之一。

Objective To observe the efficacy of Dazhu Hongjingtian Injection for acute recurrent cerebral infarction. Methods One hundred patients with acute recurrent cerebral infarction were randomized to control group or treatment group,with 50 cases in each group. Both groups were treated with conventional therapy,based on which the control group was given Aspirin Enteric-Coated Tablets orally,while the treatment group was given intravenous drip of Dazhu Hongjingtian Injection on the basis of therapeutic regimen performed in the control group,both groups were treated for two weeks. Changes in hemodynamic indices,levels of plasma thrombomodulin( TM),tissue plasminogen activator inhibitor( PAI),tissue plasminogen activator( t-PA),D-dimer( D-D) and vascular endothelial growth factor( VEGF),and clinical efficacy were compared between the two groups. Results After treatment,the treatment group obtained lower whole blood high shear viscosity,plasma high shear viscosity,TM,PAI and D-D and higher t-PA and VEGF compared with the control group( all P < 0. 05). The treatment group was superior to the control group in efficacy( P < 0. 05).Conclusion Dazhu Hongjingtian Injection has definite efficacy for acute recurrent cerebral infarction in combination of conventional therapy,up-regulation of patient’s VEGF level may be one of its therapeutic approaches.