补肾活血汤治疗精索静脉曲张性不育症的临床疗效及对附睾功能、精子活力的影响

Clinical efficacy of Bushen Huoxue decoction in treating varicocele infertility and its effect on epididymis function and sperm vitality

目的研究补肾活血汤治疗精索静脉曲张性不育症的临床疗效及对附睾功能、精子活力的影响。方法选择2016年8月～2018年7月期间在本院接受诊治的98例精索静脉曲张的男性不育症患者,参照随机数表法将患者分为对照组49例和研究组49例。对照组患者给予迈之灵加五子衍宗丸治疗;研究组患者给予补肾活血汤治疗。治疗12周后对患者的临床疗效进行评价,比较两组患者治疗前后精液质量(包括精液量、精子密度、精子活率、前向运动精子)、性激素、精浆中性α-糖苷酶变化情况。治疗结束后随访3个月,观察患者配偶受孕情况。结果治疗后研究组患者临床总有效率87.76%,对照组患者临床总有效率69.39%;研究组患者精液质量、性激素、中性α-糖苷酶水平均优于对照组(P<0.05)。结论补肾活血汤治疗精索静脉曲张性不育临床疗效显著,能够提高患者的精液质量、提高睾酮水平和精浆中性α-糖苷酶水平,改善精索静脉曲张患者生育能力,值得临床推广。

Objective To study the clinical efficacy of Bushen Huoxue decoction in the treatment of varicocele infertility and its influence on epididymis function and sperm vitality.Methods A total of 98 patients with varicocele infertility who were treated in our hospital from August 2016 to July 2018 were selected.The patients were randomly divided into control group of 49 cases and study group of 49 cases.The patients in the control group were treated with Maizhiling plus Wuzi Yanzong pill;the patients in the study group were treated with Bushen Huoxue decoction.After 12 weeks of treatment,the clinical efficacy of the patients was evaluated.The semen quality(including semen volume,sperm density,sperm motility,forward-moving sperm),sex hormones,and seminal plasma neutralα-glucosidase in the two groups were compared before and after treatment.After the end of treatment,the patients were followed up for 3 months to observe the pregnancy of the patients'spouse.Results After treatment,the total effective rate of the study group was 87.76%,and the total effective rate of the control group was 69.39%.The semen quality,sex hormone and neutralα-glucosidase levels in the study group were better than those in the control group(P<0.05).Conclusion Bushen Huoxue decoction has a significant clinical effect in treating varicocele infertility.It can improve the semen quality,improve testosterone level and seminal plasma neutralα-glucosidase level,and improve the fertility of patients with varicocele.It is worthy of clinical promotion.