Stat3、STC2在喉癌组织中的表达及意义

Expression and significance of Stat3 and STC2 in laryngeal carcinoma

目的探讨信号转导和转录激活因子3(Stat3)、斯钙素2(STC2)在喉癌组织中的表达及意义。方法回顾性选取2015年1月至2017年12月保存的喉癌组织标本67份,同时选取41份癌旁组织作为对照。采用免疫组化法检测Stat3和STC2蛋白表达以及与临床病理特征的联系。分析STC2蛋白表达与Stat3蛋白表达相关性。结果喉癌组织STC2和Stat3蛋白阳性表达率(61.19%和41.79%)明显高于癌旁组织(4.88%和0)(P<0.05);STC2蛋白表达与患者年龄、性别和肿瘤部位无关(P>0.05),与临床分期、T分期、分化程度和淋巴结转移有关,其中临床分期Ⅰ~Ⅱ期、T1~T2期、高分化和无淋巴结转移患者STC2蛋白阳性表达率(45.65%、50.00%、38.71%和42.86%)低于Ⅲ~Ⅳ期、T3~T4期、中低分化和有淋巴结转移患者(95.24%、77.78%、80.56%、81.25%)(P<0.05);Stat3蛋白表达与患者年龄、性别、临床分期、T分期、肿瘤部位、分化程度和淋巴结转移无关(P>0.05);STC2蛋白表达与Stat3蛋白表达无相关性(P>0.05)。结论Stat3、STC2在喉癌组织中的表达明显增加,其中STC2表达与患者临床病理特征有关,而Stat3表达与患者临床病理特征无关。

Objective To investigate the expression and significance of signal transduction and transcriptional activator 3(Stat3)and stanniocalcin 2(STC2)in laryngeal carcinoma.Methods 67 specimens of larynx tissue preserved in our hospital from January 2015 to December2017 were selected,and 41 paracancerous tissues were selected as control,the expression of Stat3 and STC2 protein was detected by immunohistochemistry.Results The positive expression rates of STC2 and Stat3 protein in laryngeal cancer tissues(61.19%and 41.79%)were significantly higher than those in adjacent tissues(4.88%and 0)(P<0.05).The expression of STC2 protein was not related to age,sex and location of tumors(P>0.05),but was related to clinical stage,T stage,differentiation degree and lymph node metastasis.The positive expression rates of STC2 protein in clinical stageⅠ-Ⅱ,T1-T2,highly differentiated and non-lymph node metastasis patients(45.65%,50.00%,38.71%and42.86%)were lower than those of patients with stageⅢ-Ⅳ,T3-T4,moderate or low differentiation and lymph node metastasis(95.24%,77.78%,80.56%,81.25%)(P<0.05).Stat3 protein expression was not correlated with age,sex,clinical stage,T stage,tumor location,differentiation degree and lymph node metastasis(P>0.05).STC2 protein expression was not correlated with Stat3 protein expression(P>0.05).Conclusion The expression of Stat3 and STC2 in laryngeal carcinoma tissues increase significantly,and the expression of STC2 is correlated with the clinicopathological characteristics,the expression of Stat3 is not related to the clinicopathological characteristics.