摘要
耐药性癫痫是临床上癫痫防治的重大难题。癫痫动物模型是研究癫痫发病机制及筛选抗癫痫药物和探究药物作用机制的有力工具,6Hz角膜点燃癫痫模型是一种优良的耐药性癫痫动物模型,被美国NIH推荐用于评价新药对抗耐药性癫痫的筛选工具。然而,迄今国内外未见6Hz点燃癫痫动物模型的系统报道,现从该模型的发展历史、制作方法、症状表现、致病机制和应用现状等方面进行综述,以期提供一种探究耐药性癫痫发病机制和筛选耐药性癫痫治疗药物的有力工具和标准模型。
Drug resistance is a major problem in the prevention and treatment of epilepsy.Animal models of epilepsy are powerful tools to study the mechanism of epilepsy,screening antiepileptic drugs,and explore the mechanisms of drug actions.The 6 Hz corneal kindling seizure model is an excellent animal model of drug-resistant epilepsy,which is recommended by the NIH as a screening tool to evaluate new drugs against drug-resistant epilepsy.However,there is currently no systematic report of this model.Here,we review the development history,production method,symptoms,pathogenesis,and application status of the model to provide a reference to explore the pathogenesis of drug-resistant epilepsy and screening drugs for the treatment of drug-resistant epilepsy.
作者
高青
曾贵荣
欧阳冬生
GAO Qing;ZENG Guirong;OUYANG Dongsheng(Hunan Key Laboratory of Pharmacogenetics,Changsha 410078;Institute of Clinical Pharmacology,Central South University;Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples,Changsha 410000;Institute of Medicinal PlantBeijing Union Medical College,Beijing 100193;Hunan Provincial Center for Drug Safety Evaluation and Research/HunanKey Lab of New Drug Efficacy and Safety Evaluation,Changsha 410331)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2019年第3期393-398,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
国家科技重大专项基于药物基因组学的示范性新药临床评价技术平台建设(2017ZX09304014)~~
关键词
癫痫
6Hz
点燃
动物模型
epilepsy
6 Hz
corneal kindling
animal model
