焦虑抑郁情绪对冠心病患者血管内皮细胞功能的影响

The effect of anxiety and depression on vascular endothelial function in patients with coronary heart disease

目的探究焦虑抑郁情绪对冠心病患者血管内皮功能的影响。方法根据冠心病患者是否合并焦虑抑郁情绪分为冠心病组(n=50)、冠心病合并焦虑抑郁组(n=57)和健康人群为对照组(n=48)。采用血管内皮功能监测仪EndoPAT2000(以色列,Itamar.公司)测定血管内皮功能指数(RHI)评估血管内皮功能,比较三组之间RHI差别并分析相互关系。结果冠心病组患者的RHI(1.41±0.36)、冠心病合并焦虑抑郁组患者的RHI(1.21±0.35)与对照组(2.55±0.18)相比明显减低(P<0.05),冠心病合并焦虑抑郁组患者的RHI与非焦虑抑郁组相比更低,差异有统计学意义(P<0.05)。结论冠心病患者存在血管内皮功能受损,而且合并焦虑抑郁对血管内皮损伤更重,焦虑抑郁情绪是血管内皮功能损伤的重要危险因素之一。

Objective To investigate the effect and mechanism of anxiety and depression on vascular endothelial function in patients with coronary heart disease.Methods Selected patients with established coronary heart disease(n=50)and coronary heart disease with anxiety and depression(n=57)and control group(n=48)were retrospectively analyzed.Endothelial function was evaluated by the reactive hyperemia index(RHI)with Endo PAT2000.The RHI of three groups were ompared.Results There were significantly lower in the level of RHI between coronary heart disease group(1.41±0.36)and coronary heart disease with anxiety and depression group(1.21±0.35),compared with the control group(2.55±0.18),it was significantly reduced(P<0.05).Compared with the coronary heart disease without anxiety and depression,the patients with anxiety and depression also showed significantly attenuated RHI(P<0.05).Conclusion The vascular endothelial dysfunction is more obvious in coronary heart disease patients with anxiety and depression.Anxiety and depression is an independent risk factor for the vascular endothelial dysfunction.