西比灵对高脂血症大鼠脑梗死影响的研究

Effect of sibelium on stroke in experimental hyperlipidemic rats

目的 观察西比灵对实验性高脂血症大鼠急性脑缺血的影响。方法 采用实验性高脂血症动物模型 ,研究了服用西比灵 0 5和 1 5mg·kg-1·d-1,连续 16周 ,对大鼠血浆脂质、血小板聚集性的影响以及对大脑中动脉结扎后脑梗死体积的影响。结果 西比灵两剂量组均降低实验性高脂血症大鼠的血小板聚集性和脑梗死的梗死体积 ;同时使血浆甘油三酯(TG)降低 ,0 5mg·kg-1·d-1还升高高密度脂蛋白 (HDL) ,但对血浆总胆固醇 (CHO)及血浆低密度脂蛋白 (LDL)无影响。结论 西比灵长程给药对高脂血症大鼠脑梗死有防治作用。

Objective Effect of Sibelium on stroke was evaluated in experimental hyperlipidemic rats, which were underwent 16 weeks treatment of Sibelium (0.5 and 1.5 mg·kg -1·d -1, po). Results It was shown that Sibelium significantly minimized infarct volume of brain after occlusion of the middle cerebral artery, inhibited the maximum aggregation rate of platelets, decreased TG, and 0.5 mg·kg -1·d -1 increased HDL. Conclusion All above indicated that long term intake of Sibelium could have preventive and protective effect on experimental stroke.