促甲状腺激素检测在甲状腺乳头状癌诊断中的应用价值

The application value of thyroid stimulating hormone in the diagnosis of papillary thyroid carcinoma

目的:探讨促甲状腺激素(thyroid stimulating hormone,TSH)检测在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)诊断中的应用价值。方法:选取75例拟进行择期甲状腺结节切除术治疗的甲状腺结节患者作为研究对象,按照病例结果分为PTC组(n=36)和良性结节组(n=39),对两组患者血清TSH水平差异及不同血清TSH水平人群PTC患病率进行比较。结果:PTC组患者血清TSH水平显著高于良性结节组(P<0.05);PTC组中Ⅲ~Ⅳ期患者血清TSH水平显著高于Ⅰ~Ⅱ期患者(P<0.05);PTC发病率随着血清TSH的水平的升高而升高。结论:血清TSH水平与PTC患者的发病和病情严重程度相关,血清TSH水平升高可作为甲状腺乳头状癌诊断中的一项参考指标。

Objective:To investigate the application value of thyroid stimulating hormone(TSH)in the diagnosis of papillary thyroid carcinoma(PTC).Methods:Seventy-five patients with thyroid nodules scheduled for selective thyroidectomy were selected and divided into a PTC group(n=36)and a benign nodule group(n=39)according to their case results.The difference of serum TSH level between the two groups and the prevalence of PTC in different groups with different serum TSH levels were compared.Results:The serum TSH levels were significantly higher in the PTC group than benign nodule group(P<0.05).The serum TSH level in patients with stage III-IV was significantly higher than that in patients with stage I-II(P<0.05).The incidence of PTC increased with the increase of serum TSH level.Conclusion:The serum TSH level is correlated with the severity of PTC.The elevated serum TSH level can be used as a reference index for the diagnosis of thyroid papillary carcinoma.