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经阴道彩色多普勒超声联合血清糖链抗原125和人附睾蛋白4水平检测对卵巢癌的诊断价值 被引量:16

Diagnostic value of transvaginal color Doppler sonography combined with serum carbohydrate antigen 125 and human epididymis protein 4 in ovarian cancer
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摘要 目的探讨经阴道彩色多普勒超声(TVCDS)联合血清人附睾蛋白4(HE4)和糖链抗原125(CA125)水平检测在卵巢癌诊断中的应用价值。方法选择2016年8月至2018年7月郑州市第二人民医院收治的41例卵巢癌患者(卵巢癌组)和41例卵巢良性病变患者(卵巢良性病变组)为研究对象,另选取41例同期健康体检者为健康对照组,所有受试者接受TVCDS检查,并检测血清CA125、HE4水平;对3组受试者Finkler超声评分及血清CA125、HE4水平进行比较,并分析TVCDS及血清CA125、HE4水平联合检测对卵巢癌的诊断价值。结果卵巢癌组患者Finkler超声评分及血清CA125和HE4水平显著高于卵巢良性病变组和健康对照组(P<0.05),卵巢良性病变组患者Finkler超声评分及血清CA125和HE4水平显著高于健康对照组(P<0.05),Ⅲ+Ⅳ期卵巢癌患者Finkler超声评分及血清CA125和HE4水平显著高于Ⅰ+Ⅱ期患者(P<0.05)。TVCDS及血清CA125、HE4水平联合检测诊断卵巢癌的阳性率、准确度高于三者单独检测(P<0.05);但三者联合检测与单独检测诊断卵巢癌的特异度比较差异无统计学意义(P>0.05)。结论TVCDS及血清CA125、HE4水平联合检测可有效提高卵巢癌阳性检出率及准确度,且能为卵巢癌病理分期提供参考。 Objective To investigate the value of transvaginal color Doppler sonography(TVCDS)combined with serum human epididymal protein 4(HE4)and carbohydrate antigen 125(CA125)in the diagnosis of ovarian cancer.Methods Forty-one patients with ovarian cancer(ovarian cancer group)and 41 patients with benign ovarian lesion(benign ovarian lesion group)in the Second People′s Hospital of Zhengzhou City from August 2016 to July 2018 were selected as the subjects,and forty-one healthy subjects in the same period were selected as healthy control group.All subjects were examined by TVCDS,and the levels of serum CA125 and HE4 were measured.The Finkler ultrasound score and the levels of serum CA125 and HE4 were compared among the three groups.The diagnostic value of TVCDS combined with the levels of serum CA125 and HE4 in ovarian cancer was analyzed.Results The Finkler ultrasound score and the levels of serum CA125 and HE4 in ovarian cancer group were significantly higher than those in the benign ovarian lesions group and the healthy control group(P<0.05).The Finkler ultrasound score and the levels of serum CA125 and HE4 in the benign ovarian lesion group were significantly higher than those in the healthy control group(P<0.05).The Finkler ultrasound score and the levels of serum CA125 and HE4 in patients with stageⅢ+Ⅳovarian cancer were significantly higher than those in patients with stageⅠ+Ⅱovarian cancer(P<0.05).The positive rate and accuracy of combined detection of TVCDS and the levels of serum CA125 and HE4 in the diagnosis of ovarian cancer were higher than those of single detection(P<0.05),but there was no significant difference in the specificity between combined detection and single detection of them in the diagnosis of ovarian cancer(P>0.05).Conclusion The combined detection of TVCDS and the levels of serum CA125 and HE4 can effectively improve the positive detection rate and accuracy of ovarian cancer,and can provide reference for pathological staging of ovarian cancer.
作者 韩碧波 魏海东 郑磊 宋喜亮 田振英 王桂花 HAN Bi-bo;WEI Hai-dong;ZHENG Lei;SONG Xi-liang;TIAN Zhen-ying;WANG Gui-hua(Department of Ultrasound Imaging,the Second People′s Hospital of Zhengzhou City,Zhengzhou 450000,Henan Province,China;Department of Clinical Laboratory,the Second People′s Hospital of Zhengzhou City,Zhengzhou 450000,Henan Province,China;Department of Gynecology and Obstetrics,the Second People′s Hospital of Zhengzhou City,Zhengzhou 450000,Henan Province,China)
出处 《新乡医学院学报》 CAS 2019年第10期971-974,共4页 Journal of Xinxiang Medical University
关键词 经阴道彩色多普勒 糖链抗原125 人附睾蛋白4 卵巢癌 transvaginal color Doppler sonography carbohydrate antigen 125 human epididymis protein 4 ovarian cancer
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