ROC曲线评估PET/CT联合血清CY21-1诊断肺癌的价值分析

Evaluation of the Value of PET/CT Combined with Serum CY21-1 in the Diagnosis of Lung Cancer by ROC Curve

目的探讨正电子发射计算机断层显像(positron emissiomtomography,PET)/计算机X线断层显像(computertomography,CT)联合血清细胞角蛋白19片段(Cytokeratin-19-fragment,CY21-1)诊断肺癌的临床价值。方法选取2017年7月-2018年10月期间本院呼吸科收治的肺癌或肺良性疾病患者为研究对象。肺癌患者(肺癌组)76例,肺良性疾病(肺良性组)患者65例。回顾性患者PET/CT影像图片及血清CY21-1检查结果,分析两组血清CY21-1水平差异,PET/CT、血清CY21-1单独诊断及联合诊断效能。结果76例肺癌患者中,PET/CT检出69例阳性;肺癌组血清CY21-1水平显著高于肺良性组(P<0.05);经受试者工作特征曲线(receiver operating characteristic curve,ROC)分析,PET/CT联合血清CY21-1诊断曲线下面积(Area Under Curve,AUC)为0.847,灵敏度为96.05%,均高于PET/CT和血清CY21-1单独诊断。结论相对于单独指标诊断,PET/CT联合血清CY21-1能更有助于肺癌的早期检出。

Objective To investigate the clinical value of positron emission tomography(PET)/computed tomography(CT)combined with serum cytokeratin 19 fragment(CY21-1)in the diagnosis of lung cancer.Methods Patients with lung cancer or benign lung diseases admitted to the hospital from July 2017 to October 2018 were selected as subjects,including 76 patients with lung cancer(lung cancer group)and 65 patients with benign lung diseases(benign group).The PET/CT images and examination results of serum CY21-1 were retrospectively analyzed.The difference in serum CY21-1 level,diagnostic efficiencies of PET/CT,serum CY21-1 alone and combined diagnosis were analyzed.Results Among 76 patients with lung cancer,69 positive cases were detected by PET/CT.The serum CY21-1 level in lung cancer group was significantly higher than that in benign group(P<0.05).The receiver operating characteristic curve(ROC)analysis showed that the area under curve(AUC)of PET/CT combined with serum CY21-1 was 0.847,and the sensitivity was 96.05%.Both were higher than those of PET/CT or serum CY21-1 alone.Conclusion PET/CT combined with serum CY21-1 is more helpful for the early detection of lung cancer than the diagnosis of individual indicators.