蔓荆子化学成分的研究

Chemical constituents of Viticis Fructus

目的对马鞭草科牡荆属植物单叶蔓荆果实的化学成分进行系统研究。方法采用Silica gel,Sep⁃hadex LH-20,ODS,MCI等色谱方法及制备型高效液相色谱(PHPLC)等技术对蔓荆果实的化学成分进行分离纯化,通过理化性质、磁共振波谱、质谱等技术方法进行化合物结构鉴定。结果从蔓荆子乙醇提取物中分离得到15个化合物,分别鉴定为:agestricin D(1)、5,3′-二羟基-6,7,4′-三甲氧基二氢黄酮(2)、猫眼草酚D(3)、紫花牡荆素(4)、vitetrifolin F(5)、4β,10α-香木兰烷二醇(6)、(E)-3,3′-二甲氧基-4,4′-二羟基二苯乙烯(7)、(8R)-evofolin B(8)、ω-hydroxypropioguaiacone(9)、覆盆子酮(10)、对羟基苯乙酮(11)、α-羟基香荚兰乙酮(12)、苄基-β-D-葡糖苷(13)、云杉苷(14)和4-(4′-羟基苯基)-2-丁酮-4′-O-β-D-吡喃葡糖苷(15)。结论化合物7、8、10、13、14、15为首次从牡荆属植物中分离得到。

Objective To investigate the chemical constituents of the fruits of Vitex trifolia Linn.var.simplicifo⁃lia Cham(Viticis Fructus,VF).Methods Various column chromatographic techniques(Silica gel,Sephadex LH-20,ODS,and MCI)and preparative high performance liquid chromatography(PHPLC)were employed to separate the chem⁃ical constituents of the ethanolic extracts of VF.The chemical structures of the isolated compounds were identified accord⁃ing to the physicochemical properties as well as the NMR and MS data.Results The isolated fifteen compounds from the ethanol extract of VF were identified as agestricin D(1),5,3′-dihydroxy-6,7,4′-trimethoxyflavanone(2),chryso⁃splenol D(3),casticin(4),vitetrifolin F(5),4β,10α-aromadendranediol(6),(E)-3,3′-dimethoxy-4,4′-dihy⁃droxystilbene(7),(8R)-evofolin B(8),ω-hydroxypropioguaiacone(9),4-(4-hydroxyphenyl)-2-butanone(10),4-hy⁃droxyacetophenone(11),α-hydroxyacetovanillone(12),benzyl-β-D-glucopyranoside(13),picein(14),and 4-(4′-hydroxyphenyl)-2-butanone-4′-O-β-D-glucopyranoside(15),respectively.Conclusion Compounds 7,8,10,and 13-15 are obtained from the genus Vitex for the first time.