喜炎平注射液在儿科领域的应用现状

Present clinical application of Xiyanping injection in pediatric field

喜炎平注射液为水溶性穿心莲总内酯磺化物水溶制剂,具有抗炎抗菌、抗病毒、保肝利胆、免疫调节、抗血小板聚集、抗肿瘤等作用,通过抑制单核巨噬细胞,增强巨噬细胞的吞噬功能抑制炎性因子释放;减少细胞因子的释放,阻止蛋白质对DNA片段的包裹,抑制病毒的复制;从而起到显著的抗炎、抗菌、抗病毒作用,因此广泛应用于在呼吸、消化、循环、血液、神经系统等病毒和(或)细菌感染疾病的治疗,且疗效显著。但也有相关文献指出喜炎平注射液在临床应用,由于小儿个体的差异性及身体处于发育时期,且喜炎平为中药制剂,有大分子蛋白进入机体后能激活补体产生过敏毒素,引起组胺释放,配伍上存在禁忌以及用量的不同,从而使患儿部分患儿在使用喜炎平过后发生皮肤及其附件损、胃部不适、腹痛、腹泻等不良反应。故应在严格掌握药品的适应证、禁忌证的情况下,仔细询问药物过敏史,合理用量,加强输液过程的观察和监护,尽量避免不良反应的发生。

Xiyanping injection is a water-soluble preparation of andrographolidesulfonate,which has anti-inflammatory,anti-bacterial and anti-viral effect.It also has the effect of protecting liver and gallbladder,regulating immune function and fighting against platelet aggregation and neoplasm.It inhibits the release of inflammatory factors by inhibiting mononuclear phagocytes and enhancing the phagocytosis of macrophages;it decreases the release of cytokines,prevents the wrapping of DNA segment by protein,and inhibits the copying of viruses,so as to play a significant role in anti-inflammatory,anti-bacterial and anti-viral actions.Therefore,it has been widely used in the treatment for viral and/or bacterial infectious diseases in respiratory,digestive,and nervous systems,and the effect is significant.However,it is also pointed out in some related literatures that in the clinical application of Xiyanping injection,due to the individual differences of children during growth and development,and because Xiyanping is a Chinese preparation,which can activate complements to produce allergic toxin and induce the release of histamine after the large molecular weight protein enters the human body,there is taboo in compatibility and difference in dose,so some children have adverse reactions after being given Xiyanping injection,such as damage to the skin and its appendages stomach discomfort,abdominal pain and diarrhea.Therefore,when Xiyanping injection is used,it is necessary to strictly assess the indications and contradications,carefully inquire the drug allergic history,give the proper dose and enhance the observation and monitoring during transfusion in order to avoid the occurrence of adverse reactions.