静脉溶栓治疗对急性脑梗死患者氧化应激指标与神经功能的影响

Effect of intravenous thrombolytic therapy on oxidative stress index and neurological function in patients with acute cerebral infarction

目的探讨静脉溶栓治疗急性脑梗死患者的临床疗效及对氧化应激指标与神经功能的影响。方法选择本院2015年1月~2018年12月收治的以急性脑梗死为诊断的患者80例,抽签法分为对照组(n=40)与实验组(n=40),其中对照组患者采取常规治疗(抗自由基、抗血小板聚集),实验组患者采取静脉溶栓治疗。对两组患者治疗前后氧化应激指标(SOD、MDA)、神经功能指标(NIHSS)、肢体运动功能及治疗疗效进行比较。结果治疗前,两组患者机体内氧化应激反应指标、神经功能指标NIHSS、Barthel评分比较,差异无统计学意义(P>0.05)。治疗后,两组患者机体内氧化应激反应指标均明显改善,其中实验组患者SOD反应指标明显高于对照组,而MDA指标明显低于对照组,两组患者在治疗后NIHSS评分明显降低,Barthel评分明显升高,其中实验组患者明显优于对照组,实验组患者治疗后临床总有效率为92.50%,高于对照组的65.00%,差异有统计学意义(P<0.01)。实验组患者治疗期间并发症发生率为7.50%,高于对照组的5.00%,经对症治疗后症状消失,但差异无统计学意义(P>0.05)。结论在急性脑梗死患者的治疗中,采取静脉溶栓治疗,可明显减轻患者机体内氧化应激指标,改善神经功能,提高肢体运动功能,提高临床治疗效果。

Objective To explore the clinical efficacy of intravenous thrombolytic therapy in patients with acute cerebral infarction and its influence on oxidative stress index and neurological function. Methods A total of 80 patients who were diagnosed with acute cerebral infarction and treated in our hospital from January 2015 to December 2018 were selected. They were divided into the control group(n=40) and the experimental group(n=40) according to lottery method.The control group received routine treatment(anti-free radical, anti-platelet aggregation), and the experimental group was treated with intravenous thrombolysis. The oxidative stress index(SOD, MDA), neurological function index(NIHSS),limb motor function and therapeutic efficacy between two groups were compared before and after treatment. Results There were no significant differences in the oxidative stress response index, neurological function index NIHSS or Barthel score between the two groups before treatment(P>0.05). After treatment, the oxidative stress response indexes of the two groups were significantly improved. The SOD response index of the experimental group was significantly higher than that of the control group, while the MDA index was significantly lower than that of the control group. The NIHSS scores of the two groups were significantly lower after treatment. The Barthel score was significantly higher, and the score of the experimental group was significantly better than that of the control group. The total effective rate after treatment in the experimental group was 92.50%, which was higher than that of the control group(65.00%). The difference between two groups was statistically significant(P<0.01). The complication rate of the experimental group was 7.50%,which was higher than that of the control group(5.00%), and the symptoms disappeared after symptomatic treatment, but the difference was not statistically significant(P>0.05). Conclusion In the treatment of patients with acute cerebral infarction, intravenous thrombolytic therapy can significantly reduce the oxidative stress index in patients, improve neurological function, improve limb motor function, and improve clinical treatment effect.