五氟苯酚的合成工艺研究

Synthesis of Pentafluorophenol

研究了一种五氟苯酚的合成方法。以五氟苯为原料,不经氯化或溴化,直接经格氏反应、氧化反应得到产物,反应总收率为80.0%,气相色谱检测纯度为99.0%。与相关文献对比,此工艺具有合成路线短、反应温和、收率高、纯度好以及成本低等优点,适合工业化生产。

Pentafluorophenol was synthesized with pentafluorobenzene as raw material in Grignard and oxidation processes directly without chlorination or bromination. The total yield was 80.0% and the purity was 99.0% by GC. Compared with other processes in references, this process has the advantages of short route, mild reaction, high yield, good purity and low cost, which is suitable for industrial production.