从风论治咳嗽变异性哮喘用药规律研究

Study on the medication rule of cough variant asthma from the perspective of wind theory

目的分析从风论治咳嗽变异性哮喘(CVA)的处方用药规律。方法采用计算机检索,将“咳嗽变异性哮喘”或“风咳”与“从风论治”“风”“疏风”“祛风”分别组合,检索1979年1月~2019年7月CNKI、维普、万方数据库收录的从风论治CVA的相关文献,逐层筛选,最终将纳入的文献录入中医传承辅助平台软件,分析处方用药规律。结果本研究最终纳入文献127篇,收集处方127个,包含中药120味,分析处方中用药及使用频次结果,使用频次在20次以上的中药从高到低依次为蝉蜕、甘草、苦杏仁、麻黄等,得到基于关联规则的组方用药模式。发现核心药物组合8个,演化出候选新方4个。结论从风论治CVA处方中药物多为疏风散热、祛风解表、清热息风、宣肺止咳之用,注重风药与止咳药、宣肺药、活血通络药等的配伍应用,为本病患者从风论治的临床用药提供参考。

Objective To analyze the prescription medication rule of cough variant asthma(CVA)from the perspective of wind theory.Methods By using computer retrieval,combinated of“cough variant asthma”or“wind cough”and“treatment from wind”,“wind”,“dispelling wind”and“expelling wind”.The literatures about treating CVA from wind theory were retrieved from CNKI,VIP database,and Wanfang data knowledge service platform from January 1979 to July 2019.Then,the data was put into the software of Chinese medicine inheritance assistant platform to analyze the rule of prescription medication.Results The study eventually included 127 articles and 127 prescriptions,including 120 herbal medicine.The herbal medicine's use and frequency was analyzed,more than 20 times were Periostracum Cicadae,Radix Glycyrrhizae,Semen Armeniacae Amarum,Herba Ephedrae,etc,then the use pattern of prescription was got.Eight core drug combinations and four new candidates were found.Conclusion The prescriptions for CVA treated by wind theory are mostly used for dispersing wind and dissipating heat,dispelling wind and resolving exterior symptoms,clearing away heat and resolving wind,dispersing lung and relieving cough.Emphasis is laid on the compatibility and application of wind medicine with cough-relieving drugs,lung-promoting drugs,blood-activating and collateral-dredging drugs,etc,so as to provide reference for the clinical medication of the patients treated by wind.