小儿解表口服液联合小儿氨酚黄那敏颗粒治疗小儿外感发热的临床研究

Clinical study of Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules in the treatment of exogenous fever in children

目的探讨小儿解表口服液联合小儿氨酚黄那敏颗粒治疗小儿外感发热的临床效果及安全性。方法选择2018年7月—2019年4月山东省滨州市人民医院收治的外感发热患儿230例为研究对象。依照随机数字表法分为对照组(115例)和观察组(115例)。对照组给予小儿氨酚黄那敏颗粒治疗,观察组给予小儿解表口服液联合小儿氨酚黄那敏颗粒治疗,两组连续治疗3 d。治疗后评价临床疗效。比较两组退热起效时间、解热时间及完全退热时间。比较两组治疗前后中医证候积分和血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、γ干扰素(IFN-γ)、C反应蛋白(CRP)水平。记录并比较两组治疗过程中不良反应的发生情况。结果观察组总有效率高于对照组(P<0.01)。观察组退热起效时间、解热时间及完全退热时间短于对照组(均P<0.01)。两组治疗前中医证候积分比较,差异无统计学意义(P>0.05);治疗后,两组中医证候积分低于治疗前,且观察组低于对照组(均P<0.01)。治疗前,两组血清TNF-α、IL-1β、IFN-γ及CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组血清TNF-α、IL-1β、IFN-γ及CRP水平低于治疗前,且观察组低于对照组(均P<0.05)。治疗期间,两组均未发生严重的不良反应。结论小儿解表口服液联合小儿氨酚黄那敏颗粒治疗小儿外感发热临床疗效明确,能缩短退热时间,改善临床症状,降低血清炎症因子水平,且具有较好的安全性。

Objective To investigate the clinical efficacy and safety of Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules in the treatment of exogenous fever in children.Methods From July 2018 to April 2019,230 children with exogenous fever who admitted to Binzhou People′s Hospital of Shandong Province were selected as objects.According to the random number table method,they were divided into control group(115 cases)and observation group(115 cases).Control group was treated with Xiaoer Paracetamol Huangnamin Granules,while observation group was treated with Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules.Both groups were given continuous treatment for three days.The clinical efficacy was evaluated after treatment.The antipyretic onset time,antipyretic time and complete antipyretic time of two groups were compared.The TCM syndrome scores and serum tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),γinterferon(IFN-γ)and C-reactive protein(CRP)levels were compared between two groups before and after treatment.The incidence of adverse reactions during the treatment was recorded and compared between two groups.Results The total clinical effective rate of observation group was higher than that of control group(P<0.01).The antipyretic onset time,antipyretic time and complete antipyretic time of observation group were shorter than those of control group(all P<0.01).There was no statistically significant difference in TCM syndrome scores between two groups before treatment(P>0.05);TCM syndrome scores in two groups after treatment were lower than those before treatment,and observation group was lower than control group(all P<0.01).Before treatment,there was no significant difference in serum TNF-α,IL-1β,IFN-γand CRP levels between two groups(P>0.05);after treatment,the levels of serum TNF-α,IL-1β,IFN-γand CRP in two groups were lower than those before treatment,and observation group was lower than control group(all P<0.05). During the treatment period, no serious adverse reactions occurred in both groups. Conclusion Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules has definite clinical efficacy in treating exogenous fever in children. It can shorten the antipyretic time, improve clinical symptoms and reduce the level of serum inflammatory factors, and has good safety.