可注射水凝胶治疗眼科疾病的研究进展

Research progress of injectable hydrogel in eye diseases treatment

眼部结构的特殊性使眼科疾病的治疗面临很多阻碍。水凝胶作为一种具备多维应用潜能的高分子材料,有着可控的力学性能及生物性能,是组织工程、生物工程等领域的研究热点。水凝胶良好的透明性、安全性、兼容性也提示了水凝胶在眼科领域广阔的研究前景。目前已应用于眼科的水凝胶有人工泪液、药物载体、黏附剂等。本综述介绍了可注射水凝胶在制作、性能及应用方面的特点,概述了可注射水凝胶作为药物载体、组织黏附剂、空间填充剂以及细胞载体在眼科疾病中的应用进展及挑战,特别介绍了可注射水凝胶近年来在角膜外伤、青光眼、白内障、视网膜脱离及年龄相关性黄斑变性等疾病治疗方面的研究。

The complex of eye structure makes its treatment methods face various challenges.Hydrogel is a polymer material,with multidimensional potential application.This controllable mechanical and biological properties make hydrogel as a hotspot in the field of tissue engineering and biological engineering.Meanwhile,the transparency and great biocompatibility of hydrogel indicate its application in the prospect of eyes therapies.At present,it has been used as artificial tears,drug carrier,adhesive agents in ophthalmology.This review introduced the injectable hydrogel in the aspect of production,properties,and applications.The development of injectable hydrogel as ocular drug carrier,tissue adhesives,space filling agent and cell carrier face many challenges.This article explains the recent advances in various injectable hydrogel for corneal trauma,glaucoma,cataract,retinal detachment,age-related macular degeneration.