34例糖尿病合并不射精症患者行卵细胞质内单精子注射助孕的结局分析

Analysis of the outcome of 34 diabetes patients combined with anejaculation undergoing intracytoplasmic sperm injection

目的探讨糖尿病合并不射精症患者行卵细胞质内单精子注射(ICSI)助孕的结局。方法回顾性选取2017年1月至2018年12月成都西囡妇科医院诊治的34对男性患糖尿病合并不射精症夫妻进行回顾性研究。将这34对夫妻纳入观察组,另选取410对同期男性诊断为梗阻性无精子症夫妻纳入对照组。两组观察对象均通过经皮睾丸穿刺取精(TESA)联合ICSI助孕,探讨两组观察对象基线资料和助孕结局资料。结果两组观察对象成熟卵率、受精率、优质胚胎率、临床妊娠率和流产率比较,差异均无统计学意义(均P>0.05),观察组观察对象宫外孕率、活产率均低于对照组,差异均具有统计学意义(均P<0.05)。结论糖尿病可造成男性精子损伤,对胚胎质量有一定影响,活产率较低。

Objective To investigate the outcome of intracytoplasmic sperm injection(ICSI)in patients with diabetes mellitus and anejaculation.Methods A retrospective analysis of the couples who were diagnosed and treated in Chengdu Xi′an Women′s Hospital from January 2017 to December 2018 was performed.Thirty-four males who had diabetes and anejaculation were included in the observation group,and 410 couples who were diagnosed with obstructive azoospermia in the same period were selected and included in the control group.Both groups were assisted in pregnancy by testicular epididymal sperm aspiration(TESA)combined with ICSI.The general clinical data and assisted pregnancy outcome of the two groups was compared between the two groups.Results There was no statistically significant difference in the mature egg rate,fertilization rate,high-quality embryo rate,clinical pregnancy rate,and abortion rate between the two groups(all P>0.05).The ectopic pregnancy rate and live birth rate in the observation group were lower than those in the control group,with statistically significant differences(all P<0.05).Conclusions Diabetes can cause sperm damage in men,which has a certain impact on embryo quality,thusly a low live birth rate.