卵巢癌相关糖蛋白分子标志物及其促癌机制的研究进展

Advances of Glycoproteins Associated with Ovarian Cancer as Molecular Markers and Their Cancer-Promoting Mechanisms

几乎所有肿瘤都存在蛋白质的异常糖基化修饰,糖基化修饰蛋白如肿瘤抗原125、间皮素、人附睾蛋白4等都被认为是卵巢癌诊断的重要分子标志物,同时研究发现,它们还可通过影响肿瘤的直接粘附作用、促进肿瘤进展、诱导肿瘤耐药、发挥免疫逃逸等,促进卵巢癌的发生发展和耐药。全文就糖蛋白作为分子标志物的早期诊断意义及促癌机制的研究进展进行综述。

Abnormal glycosylation of proteins is found in almost all tumors. Glycosylated modified proteins,such as cancer antigen 125(CA125),mesothelin and human epididymis protein 4(HE4)are considered as important molecular markers for the diagnosis of ovarian cancer. Meanwhile,it is found that they can promote the occurrence,development and drug resistance of ovarian cancer by affecting the direct adhesion of tumor,promoting tumor progression,inducing tumor resistance,and exerting immune escape. This article reviews the value of glycoproteins as molecular markers in the early diagnosis of ovarian cancer and the research progress of cancer-promoting mechanisms of glycoprotein,to provide reference for the clinical treatment of ovarian cancer.