纳洛酮治疗慢阻肺合并呼吸衰竭的临床疗效分析

Analysis of the clinical efficacy of naloxone in the treatment of chronic obstructive pulmonary with respiratory failure

目的分析纳洛酮治疗慢性阻塞性肺疾病(慢阻肺)合并呼吸衰竭疾病的临床效果。方法 88例慢阻肺合并呼吸衰竭患者,随机分为常规组和治疗组,每组44例。常规组行平喘、抗感染、低流量吸氧治疗,同时纠正机体水电解质紊乱、酸解失衡状态;治疗组在常规组基础上行纳洛酮治疗。比较两组治疗前后肺功能指标、血气指标及临床疗效、症状消失时间。结果治疗后,治疗组最大通气量占预计值的百分比(67.84±6.52)%、用力肺活量(3.01±0.62)L、第1秒用力呼气容积占预计值的百分比(56.13±6.08)%均高于常规组的(48.19±6.73)%、(1.78±0.34)L、(42.75±6.22)%,差异具有统计学意义(P<0.05)。治疗后,治疗组动脉血氧分压(10.23±1.39)kPa高于常规组的(8.74±1.65)kPa,动脉血二氧化碳分压(6.94±1.53)kPa低于常规组的(8.19±1.26)kPa,差异具有统计学意义(P<0.05)。治疗组治疗总有效率高于常规组,差异具有统计学意义(P<0.05)。治疗组咳嗽、咳痰、气短、呼吸困难消失时间均短于常规组,差异具有统计学意义(P<0.05)。结论纳洛酮能有效改善慢阻肺合并呼吸衰竭患者的血气指标及肺功能,加快症状缓解,效果显著。

Objective To analyze the clinical effect of naloxone in the treatment of chronic obstructive pulmonary with respiratory failure.Methods A total of 88 patients with chronic obstructive pulmonary were randomly divided routine group and control group,with 44 cases in each group.The routine group was treated with antiasthmatic,anti infection,low flow oxygen inhalation,and the imbalance of water and electrolyte and acidolysis was corrected;the treatment group was treated with naloxone on the basis of routine group.The pulmonary function indexes and blood gas indexes before and after treatment,clinical efficacy,and symptoms disappearance time were compared between the two groups.Results After treatment,the percentage of maximum ventilation to the predicted value(67.84±6.52)%,forced vital capacity(3.01±0.62)L,and the percentage of forced expiratory volume in the first second to the predicted value(56.13±6.08)%in the treatment group were all higher than(48.19±6.73)%,(1.78±0.34)L,(42.75±6.22)%in the routine group,and the difference was statistically significant(P<0.05).After treatment,the arterial partial pressure of oxygen(10.23±1.39)kPa in the treatment group was higher than(8.74±1.65)kPa in the routine group,and the arterial partial pressure of carbon dioxide(6.94±1.53)kPa was lower than(8.19±1.26)kPa in the routine group,and the difference was statistically significant(P<0.05).The total effective rate of treatment of the treatment group was higher than that of the routine group,and the difference was statistically significant(P<0.05).The disappearance time of cough,sputum,shortness of breath,and dyspnea in the treatment group was shorter than those in the routine group,and the difference was statistically significant(P<0.05).Conclusion Naloxone shows remarkable effect for patients with COPD complicated with respiratory failure,which can effectively improve blood gas indicators and lung function and speed up symptom relief.