脑和肌肉芳香烃受体核转运样蛋白1基因调控口腔及全身骨代谢的作用

Effects of brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 gene on the regulation of oral and systemic bone metabolism

近日钟基因调控哺乳动物的昼夜节律,脑和肌肉芳香烃受体核转运样蛋白1(Bmal1)基因作为其核心组分之一,与多种生物行为活动密切相关,近年来,其在调控骨代谢方面具有的重要作用也受到越来越多的关注。Bmal1基因可通过下游多种信号通路的介导,分别参与调节骨相关成骨细胞、破骨细胞及软骨细胞等细胞的生理活动,进而影响如骨质疏松、骨关节炎等骨代谢相关疾病,同时也在颌骨的生理病理过程中发挥作用。本文就Bmal1基因调控骨代谢的研究进展作一综述,为口腔及全身相关骨代谢疾病的诊疗提供可能思路。

The circadian clock gene regulates the circadian rhythm of mammals.As one of its core components,the Bmal1 gene is related to various biological behavioural activities.The role of this gene in bone metabolism has received increasing attention.The Bmal1 gene could be involved in the regulation of the physiological activities of osteoblasts,osteoclasts and chondrocytes related to bone metabolism through the downstream signalling pathways.These phenomena affect bone metabolism-related diseases,such as osteoporosis and osteoarthritis.The Bmal1 gene simultaneously plays a role in the physiological and pathological processes of the jaw.In this article,the development in the study of the Bmal1 gene regulating the physiology and pathology of bone tissue is reviewed.The results provide possible concepts for the treatment of oral and systemic bone metabolism-related diseases.