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Effect of purine-rich box1 on proliferation of fibroblasts

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摘要 Fibroblasts are pleomorphic cells that have a multi­directional effect on organ morphogenesis,tissue homeostasis,and immune response.In fibrotic diseases,fibroblasts synthesize large amounts of extracellular matrix(ECM),leading to scarring and organ failure.Purine-rich boxl(PU.I)is a specific transcription factor of hematopoietic cell and belongs to the E26 transformation specificity(ETS)family.Recently,it was found that the transcription factor PU.I is an important regulatory factor of the profibrotic gene expression program.TGF-J3 had been proved to play an important role in many ocular tissue fibrosis diseases,and up-regulated the expression of PU.I in fibroblasts producing ECM in a Smad-3 dependent manner.We explore the effect of PU.I on fibrosis of different ocular tissues from this perspective.This article reviews the role of PU.l and its effects on fibrosis of ocular tissue and other tissues.
出处 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第11期1827-1832,共6页 国际眼科杂志(英文版)
基金 Supported by the National Natural Science Foundation of China(No.81470633) the Natural Science Grant of the Heilongjiang Province of China(No.H2018035,No.LH2020H040) the Innovation and Development Foundation of the First Affiliated Hospital of Harbin Medical University(No.2018L002).
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