哌拉西林-他唑巴坦对老年脑血管病伴吸入性肺炎的疗效及机制分析

Analysis on Efficacy and Mechanism of Piperacillin-Tazobactam in the Treatment of Senile Cerebrovascular Disease Complicated with Aspiration Pneumonia

目的探讨哌拉西林-他唑巴坦对老年脑血管病伴吸入性肺炎的疗效及机制。方法选择2018年5月至2019年5月我院收治的82例老年脑血管病伴吸入性肺炎患者,随机平均分为对照组和观察组。两组均接受常规治疗。对照组采用头孢曲松钠治疗,观察组采用哌拉西林-他唑巴坦治疗,对比两组患者的治疗效果、临床症状改善时间及治疗前后的C反应蛋白、免疫球蛋白、 TNF-α水平。结果观察组的治疗总有效率为95.1%,高于对照组的80.5%(P <0.05)。观察组的肺部阴影消失时间、咳嗽缓解时间及痰菌涂片转阴时间均短于对照组(P <0.05)。治疗后,两组的C反应蛋白、 TNF-α水平均降低,免疫球蛋白水平均升高,且观察组的C反应蛋白、 TNF-α水平均低于对照组,免疫球蛋白水平高于对照组(P <0.05)。结论哌拉西林-他唑巴坦可提高老年脑血管病伴吸入性肺炎的疗效,可能与其显著改善患者的炎性因子有关。

Objective To explore the efficacy and mechanism of piperacillin-tazobactam in the treatment of senile cerebrovascular disease complicated with aspiration pneumonia.Methods 82 elderly patients with cerebrovascular disease complicated with aspiration pneumonia admitted to our hospital from May 2018 to May 2019 were selected and randomly divided into control group and observation group equally.Both groups received routine treatment.The control group was treated with ceftriaxone sodium,and the observation group was treated with piperacillin-tazobactam.The treatment effect,improvement time of clinical symptoms,and the levels of C-reactive protein,immunoglobulin and TNF-αbefore and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.1%,higher than 80.5%in the control group(P<0.05).The disappearance time of lung shadow,cough relief time and sputum smear negative time in the observation group were shorter than those in the control group(P<0.05).After treatment,the C-reactive protein and TNF-αlevels of the two groups decreased,and the immunoglobulin levels increased(P<0.05);The C-reactive protein and TNF-αlevels of the observation group were lower than those of the control group,and the immunoglobulin level was higher than that of the control group(P<0.05).Conclusions Piperacillin-tazobactam can improve the efficacy of senile cerebrovascular disease complicated with aspiration pneumonia,which may be related to the significant improvement of inflammatory factors.