育龄妇女亚甲基四氢叶酸还原酶(MTHFR)基因C677T,A1298C位点多态性与HR-HPV感染的相关性研究

Study of the Relationship between MTHFR(C677T,A1298C)Polymorphism and HR-HPV Infection in Women of Childbearing Age

目的探讨育龄妇女亚甲基四氢叶酸还原酶(MTHFR)C677T,A1298C基因多态性与高危型人乳头瘤病毒(HR-HPV)感染的相关性。方法收集2017年11月~2019年12月期间来天津市宝坻区人民医院孕检的育龄妇女所做HR-HPV及MTHFR多态性(包括C677T和A1298C)检测的样本资料共1130例,比较MTHFR各代谢型之间HR-HPV的阳性率。结果在MTHFR的三种代谢型中,弱代谢型是HR-HPV优势型别52型(χ^(2)=4.764,P=0.029,OR=1.771,95%CI:1.054~2.975)、16型(χ^(2)=4.304,P=0.038,OR=1.922,95%CI:1.027~3.599)及多重感染(χ^(2)=3.985,P=0.046,OR=1.479,95%CI:1.005~2.176)的易感型别。结论MTHFR代谢活性受C677T和A1298C位点基因的双重影响,其中的弱代谢型是HR-HPV优势型别52型和16型,以及多重感染的易感型别。

Objective To explore the relationship between MTHFRC677T and A1298C polymorphism and HR-HPV infection in women of childbearing age.Methods 1130 women of reproductive age in Tianjin Baodi Hospital tested for MTHFR C677T and A1298C polymorphism and HR-HPV infection from November 2017 to December 2019 were enrolled,and the positivity of HR-HPV among three groups of the gene expression pattern for MTHFR were compared.Results The weak metabolic group of MTHFR were susceptible to the HPV dominant type 52(χ^(2)=4.764,P=0.029,OR=1.771,95%CI:1.054~2.975)and 16(χ^(2)=4.304,P=0.038,OR=1.922,95%CI:1.027~3.599)infection,and to HPV multiple infection as well(χ^(2)=3.985,P=0.046,OR=1.479,95%CI:1.005~2.176).Conclusion C677T and A1298C polymorphism has a double effect on metabolic activity of MTHFR,and its weak metabolic group were susceptible to the HPV dominant type(52,16)and HPV multiple infection.