摘要
Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinfectants. Herein, we report an eco-friendly and efficient electrochemical strategy for inactivating the SARS-Co V-2 using in-situ formed nickel oxide hydroxide as anode catalyst and sodium carbonate as electrolyte. At a voltage of 5 V, the SARS-Co V-2 viruses can be rapidly inactivated with disinfection efficiency reaching 95% in only 30 s and 99.99% in 5 min. Mass spectrometry analysis and theoretical calculations indicate that the reactive oxygen species generated on the anode can oxidize the peptide chains and induce cleavage of the peptide backbone of the receptor binding domain of the SARS-Co V-2 spike glycoprotein, and thereby disables the virus. This strategy provides a sustainable and highly efficient approach for the disinfection of the SARS-CoV-2 viruliferous aerosols and wastewater.
当前主要采用危害生物体和环境安全的消毒剂对引起新冠肺炎的SARS-CoV-2病毒进行消杀,从而阻断病毒传播.本文报道了一种绿色、高效的电化学消杀SARS-CoV-2病毒的装置和方法:采用Ni OOH作为阳极,泡沫镍为阴极,碳酸钠为电解液,在5 V恒电压电化学处理5 min后, SARS-Co V-2病毒的灭活效率高达99.99%.质谱分析结合理论计算模拟表明,在电解过程中阳极所产生的活性氧物种能够有效氧化并破坏SARS-Co V-2病毒S1蛋白的关键受体识别区域(RBD),从而实现病毒彻底灭活.这一绿色且高效的电化学灭活策略为阻断含有SARS-Co V-2病毒的气溶胶、污水等潜在传播途径提供了新的思路.
作者
Yunchuan Tu
Wei Tang
Liang Yu
Zheyi Liu
Yanting Liu
Huicong Xia
Haiwei Zhang
Shiyun Chen
Jia Wu
Xiaoju Cui
Jianan Zhang
Fangjun Wang
Yangbo Hu
Dehui Deng
涂云川;唐薇;于良;刘哲益;刘艳廷;夏会聪;张海伟;陈士云;吴佳;崔晓菊;张佳楠;王方军;胡杨波;邓德会(State Key Laboratory of Catalysis,Collaborative Innovation Center of Chemistry for Energy Materials,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China;CAS Key Laboratory of Separation Sciences for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;University of Chinese Academy of Sciences,Beijing 100049,China;College of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450001,China;Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China)
基金
supported by the National Natural Science Foundation of China(21890753,21988101 to Dehui Deng,91853101 to Fangjun Wang,and 91845106 to Liang Yu)
the Strategic PriorityResearch Program of the Chinese Academy of Sciences(XDB36030200 to Dehui Deng)
the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y201936 to Dehui Deng,Y201750 to Yangbo Hu)。
