摘要
The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for dioxin.Almost half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and disease.In this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.
基金
This work was supported by grants NS102807,ES02530,ES029136,AI126880 from the NIH and RG-1902-33606 from the NMSS and PA-1604-08459 from the International Progressive MS Alliance.J.V.M.and P.H.F.C.were supported by Santander Universidades and by Fundação Faculdade de Medicina(FFM),São Paulo,SP,Brazil.
