奥曲肽联合凝血酶治疗肝硬化伴上消化道出血

Octreotide Combined With Thrombin in the Treatment of Liver Cirrhosis With Upper Gastrointestinal Bleeding

目的探究在肝硬化伴上消化道出血患者的临床治疗过程中运用奥曲肽联合凝血酶的临床价值及应用效果。方法本文从2019年08月—2020年07月期间本院收治的肝硬化伴上消化道出血患者中抽取114例作为对象展开研究,应用区组随机化分组法分为试验组、参比组各57例,参比组肝硬化伴上消化道出血患者给予奥曲肽治疗,试验组肝硬化伴上消化道出血患者给予奥曲肽联合凝血酶治疗,对比两组患者临床症状缓解时间、住院时长、格拉斯哥-布拉奇福德出血(GBS)评分及治疗有效率。结果试验组肝硬化伴上消化道出血患者呕血、黑便症状缓解时间、住院时长及GBS评分均明显低于参比组患者;且试验组患者临床治疗有效率显著高于参比组患者,数据差异具有统计学意义(P<0.05)。结论将奥曲肽联合凝血酶治疗应用于肝硬化伴上消化道出血患者的临床效果较为显著,有助于促进患者尽快止血恢复。

Objective To explore the clinical value and effect of octreotide combined with thrombin in the clinical treatment of liver cirrhosis patients with upper gastrointestinal bleeding.Methods 114 cases of liver cirrhosis with upper gastrointestinal bleeding in our hospital from August 2019 to July 2020 were selected and randomly divided into the experimental group and the reference group with 57 cases in each group.The reference group was given octreotide treatment,and the experimental group was given octreotide combined with upper gastrointestinal bleeding Thrombin treatment,the clinical symptom relief time,length of hospital stay,glasgow bradford bleeding(GBS)score and treatment efficiency were compared between the two groups.Results The remission time of hematemesis,melena symptoms,length of stay and GBS score of experimental group were significantly lower than those of reference group;and the clinical treatment effective rate of experimental group was significantly higher than that of reference group,and the data difference was statistically significant(P<0.05).Conclusion The clinical effect of octreotide combined with thrombin in the treatment of liver cirrhosis with upper gastrointestinal bleeding is more significant,which helps to promote the recovery of hemostasis as soon as possible.