神经系统变性病患者运用丁苯酞治疗的临床效果评价

Evaluation on clinical effect of butylphthalide in the treatment of neurodegenerative diseases

目的 分析丁苯酞治疗神经系统变性病患者的临床疗效。方法 46例神经系统变性病患者,根据治疗方法不同分为对照组与研究组,各23例。对照组给予常规治疗,研究组给予丁苯酞治疗。比较两组临床有效性、国际协作共济失调评估量表(ICARS)各项评分。结果 研究组的临床有效性为91.30%,高于对照组的65.22%,差异有统计学意义(P<0.05)。研究组的语言障碍、动态功能、眼球运动障碍、步态姿势障碍评分分别为(7.37±2.15)、(0.76±0.16)、(8.04±0.15)、(0.93±0.12)分均低于对照组的(10.15±2.67)、(1.27±0.27)、(12.73±3.17)、(1.46±0.21)分,差异有统计学意义(P<0.05)。结论 丁苯酞治疗神经系统变性病患者可取得显著疗效,改善功能障碍,值得临床推广应用。

Objective To analyze the clinical efficacy of butylphthalide in the treatment of neurodegenerative diseases.Methods A total of 46 patients with neurodegenerative diseases were divided into control group and research group according to different treatment methods,with 23 cases in each group.The control group was treated with conventional therapy,and the research group was treated with butylphthalide.Both groups were compared in terms of clinical effectiveness,International Cooperative Ataxia Rating Scale(ICARS)score.Results The clinical effectiveness of the research group was 91.30%,which was higher than 65.22%of the control group,and the difference was statistically significant(P<0.05).The scores of language disorder,dynamic function,eye movement disorder,and gait and posture disorder in the research group were(7.37±2.15),(0.76±0.16),(8.04±0.15),and(0.93±0.12)points respectively,which were lower than(10.15±2.67),(1.27±0.27),(12.73±3.17),and(1.46±0.21)points in the control group,and the differences were statistically significant(P<0.05).Conclusion Butylphthalide has significant efficacy on patients with neurodegenerative diseases,and it can improve dysfunction,which is worthy of clinical promotion and application.