短程地塞米松软膏联合他克莫司软膏治疗面部脂溢性皮炎的临床效果分析

Dexamethasone ointment combined with tacrolimus ointment in treatment of facial seborrheic dermatitis for a short course

目的短程地塞米松软膏联合他克莫司软膏治疗面部脂溢性皮炎的临床应用效果分析。方法选取广州医科大学附属第四医院2019年10月至2021年7月皮肤科门诊收治的155例面部脂溢性皮炎患者为研究对象,采用随机数字表法分为对照组和观察组。观察组77例,男39例,女38例,年龄(35.36±5.36)岁,采用短程地塞米松软膏联合0.1%他克莫司软膏涂抹患处;对照组78例,男41例,女37例,年龄(35.34±5.56)岁,单独采用0.1%他克莫司软膏涂抹。两组患者随访4周,观察并比较两组患者疾病的治疗效果及不良反应情况。结果观察组的治疗总有效率为94.8%(73/77),对照组为65.4%(51/78),两组比较差异有统计学意义(χ^(2)=20.962,P<0.001);观察组的不良反应发生率为6.5%(5/77),对照组为25.6%(20/78),差异有统计学意义(χ^(2)=8.418,P=0.004)。结论短程地塞米松软膏联合他克莫司软膏治疗面部脂溢性皮炎,在提高疗效的同时可降低不良反应发生率,值得临床推广应用。

Objective To study the clinical effect of dexamethasone ointment combined with tacrolimus ointment in the treatment of facial seborrheic dermatitis for a short course.Methods One hundred and fifty-five patients with facial seborrheic dermatitis treated at The Fourth Affiliated Hospital of Guangzhou Medical University from October 2019 to July 2021 were selected as the research objects.According to the random number table method,the 155 patients were divided into a control group(78 cases)and an observation group(77 cases).The observation group had 39 males and 38 females,were(35.36±5.36)years old,and were treated with dexamethasone ointment and 0.1%tacrolimus ointment for a short course.The control group had 41 males and 37 females,were(35.34±5.56)years old,and were treated with 0.1%tacrolimus ointment.Both groups were followed up for 4 weeks.The treatment effects and adverse reactions in both groups were observed and analyzed.Results The total effective rate was 94.8%(73/77)in the observation group and 65.4%(51/78)in the control group(χ^(2)=20.962,P<0.001).The incidence of adverse reactions was 6.5%(5/77)in the observation group and 25.6%(20/78)in the control group(χ^(2)=8.418,P=0.004).Conclusion Dexamethasone ointment combined with tacrolimus ointment in the treatment of facial seborrheic dermatitis for a short course is effective,with a low incidence of adverse reactions,so it is worth being clinically generalized.