丹参注射液与依达拉奉联合治疗急性脑梗死的疗效分析

Efficacy Analysis of Danshen Injection Combined with Edaravone in the Treatment of Acute Cerebral Infarction

目的分析丹参注射液与依达拉奉联合治疗急性脑梗死的疗效。方法选择该院2019年6月—2020年6月急性脑梗死患者共136例,数字表随机分为两组,每组68例。参照组给予丹参注射液,联合治疗组在参照组治疗的基础上加用依达拉奉。所有患者均接受两周的治疗。比较两组美国国立卫生研究院卒中量表(NIHSS)评分降低45%以上的时间、平均住院时间、治疗前后患者NIHSS评分、日常生活活动能力(ADL)评分、总有效率、不良反应。结果联合治疗组NIHSS评分降低45%以上的时间、平均住院时间(6.25±1.20)、(14.19±2.21)d短于参照组(9.51±2.34)、(18.25±3.21)d,差异有统计学意义(t=10.223、8.591,P<0.05)。联合治疗组NIHSS评分低于参照组,ADL评分高于参照组,联合治疗组总有效率为100.00%(68/68)高于参照组的70.59%(48/68),差异有统计学意义(P<0.05)。两组均未出现严重不良反应,差异无统计学意义(P>0.05)。结论丹参注射液联合依达拉奉用于急性脑梗死治疗的作用确切,可有效减轻患者的神经功能缺损,缩短住院时间且安全性高,不良反应少,值得推广和应用。

Objective To analyze the efficacy of salvia miltiorrhiza injection combined with Edaravone in the treatment of acute cerebral infarction.Methods 136 patients with acute cerebral infarction in the hospital from June 2019 to June 2020 were randomly divided into two groups:group(n=68)and combination treatment group(n=68).The control group was given Danshen injection,the combination treatment group was treated with Edaravone on the basis of the treatment of the control group.All patients received treatment for 2 weeks.The National Institutes of Health stroke scale(NIHSS)score was reduced by more than 45%,the average hospital stay,the NIHSS score before and after treatment,the score of activities of daily living(ADL),the total effective rate and adverse reactions were compared between the two groups.Results In the compinaton treatment group,the NIHSS score decreased by more than 45%,and the average hospital stay was(6.25±1.20)d and(14.19±2.21)d,which was shorter than the control group(9.51±2.34)d and(18.25±3.21)d,the difference were statistically significant(t=10.223,8.591,P<0.05).The score of NIHSS in the combination treatment group was lower than that of the control group,and the ADL score was higher than that of the control group,the total effective rate of the combination treatment group was 100.00%(68/68)higher than that of the control group 70.59%(48/68),the difference was statistically significant(P<0.05).No serious adverse reactions occurred in the two groups,the difference was not statistically significant(P>0.05).Conclusion Salvia miltiorrhiza injection combined with Edaravone is effective in the treatment of acute cerebral infarction,which can effectively reduce the neurological defect,shorten the hospitalization time,high safety and less adverse reactions,so it is worth popularizing and applying.