手指比值(2D∶4D)与精神分裂症的关系研究

Relationship between digit ratio(2D:4D)and schizophrenia

目的探究食指和无名指长度的比值(2D∶4D)在精神分裂症患者和健康人群中的差异,并分析精神分裂症患者手指比值(2D∶4D)与精神症状的相关性。方法选取2019年7月至2020年8月芜湖市第四人民医院收治的136名精神分裂症患者作为患者组,同期招募在该医院工作、学习及就诊患者家属148名健康人群作为对照组,利用Adobe Photoshop CC 19.1.3软件对两组被试者的手指照片进行测量,并采用阳性与阴性症状量表(PANSS)对精神分裂症患者的精神症状进行评定。比较两组被试者间手指比值的差异,采用Pearson相关分析患者组手指比值与精神症状的关联性。结果患者组右手的2D∶4D比值小于对照组;在不同性别中,患者组男性左右手的2D∶4D比值均大于对照组,患者组女性左右手的2D∶4D比值均小于对照组,差异有统计学意义(P<0.05)。对照组右手的2D∶4D比值大于左手,其中男性左右手的2D∶4D比值小于女性,差异均有统计学意义(P<0.05);而患者组左右手的2D∶4D比值,差异不具有统计学意义(P>0.05)。患者的左右手的2D∶4D比值与PANSS总分及各症状因子得分均不存在相关性(P>0.05)。结论精神分裂症患者的2D∶4D比值与其精神症状不存在相关性,但是存在异于健康人群的2D∶4D比值,这可能是精神分裂症的一个提示。

Objective To explore the difference in second-to-fourth digit ratio(2 D∶4 D)between schizophrenia patients and healthy people,and to analyze the correlation between digit ratio(2 D∶4 D)and psychiatric symptoms in schizophrenia patients.Methods A total of 136 schizophrenia patients treated in Wuhu Fourth People’s Hospital from July 2019 to August 2020 were selected as the patient group,and 148 healthy people who worked,studied or accompanied patients in the hospital were recruited as the control group.The digit photos of subjects were measured by Adobe Photoshop CC 19.1.3 software,and the psychiatric symptoms of schizophrenia patients were evaluated by the Positive and Negative Symptom Scale(PANSS).The difference indigit ratio between the two groups was compared,and the correlation between finger ratio and psychiatric symptoms was analyzed by Pearson correlation.Results The 2 D∶4 D ratio of the right hand in the patient group was lower thanthat in the control group.The 2 D∶4 D ratio of both hands in the male patient group was higherthan that in the control group,while the female patient group was lower than that in the control group(P<0.05).The difference in 2 D∶4 D ratio between left hand and right hand was statistically significant inthe control group,with a higher value in females than in males(P<0.05).The difference between left and right hands in the patient group was not statistically significant(P>0.05).There was no correlation between the2 D∶4 D ratio of both hands and the score of PANSS(P>0.05).Conclusions There is no correlation between the 2 D∶4 D ratio and their psychiatric symptoms in schizophrenia patients.However,the 2 D∶4 D ratio of schizophrenia patients is different from that of healthy people,which may be an indicator of schizophrenia.