肺癌组织中肿瘤转移相关基因1和血管内皮生长因子C表达与肿瘤分期和预后的关系

The relationship between the expressions of MTA1 and VEGF-C in lung cancer tissues and the tumor staging and prognosis

目的分析肺癌癌组织中肿瘤转移相关基因1(MTA1)和血管内皮生长因子C(VEGF-C)表达水平及其与肿瘤分期和预后的关系。方法我院收治的108例肺癌患者癌组织及癌旁组织标本,检测MTA1及VEGF-C表达水平并收集临床相关资料。结果癌组织中VEGF-C及MTA1阳性表达率均高于癌旁组织(P<0.05);MTA1与VEGF-C在肿瘤III~IV期、低分化、有淋巴结转移患者中阳性表达率较高(P<0.05)。VEGF-C表达与MTA1呈正相关(P<0.05);VEGF-C阳性组和MTA1阳性组1年总生存率及无进展生存率均低于阴性组(P<0.05)。结论VEGF-C与MTA1在NSCLC癌组织中存在阳性表达,两者在肿瘤血管和淋巴结生成中可能存在协同作用,共同促进肿瘤细胞的恶性发展,其阳性水平表达越高,患者预后越差。

Objective To analyze the relationship between the expression levels of tumor metastasis-associated gene 1(MTA1)and vascular endothelial growth factor C(VEGF-C)in lung cancer tissues and the tumor staging and prognosis.Methods Specimens of cancer tissues and para-cancerous tissues from 108 patients with lung cancer admitted to our hospital were collected.The expression levels of MTA1 and VEGF-C were detected and the clinical related data were collected.Results The positive expression rates of VEGF-C and MTA1 in cancer tissues were higher than those in para-cancerous tissues(P<0.05).The positive expression rates of MTA1 and VEGF-C were higher in patients with stage III-IV tumors,low differentiation and lymph node metastasis(P<0.05).The expression of VEGF-C was positively correlated with the expression of MTA1(P<0.05).The 1-year overall survival rate and progression-free survival rate in the VEGF-C positive group and the MTA1 positive group were lower than those in the corresponding negative groups(P<0.05).Conclusion VEGF-C and MTA1 are positively expressed in lung cancer tissues.The two indexes may have synergistic effects in the formation of tumor vessels and lymph nodes,which jointly promote the malignant development of tumor cells.The higher the positive levels of VEGF-C and MTA1 are,the worse the prognosis of patients is.