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柴胡疏肝散为主治疗乳腺增生疗效的Meta分析 被引量:1

Meta analysis of the efficacy of Chaihushugan powder in the treatment of hyperplasia of mammary glands
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摘要 目的系统评价柴胡疏肝散为主治疗乳腺增生的临床疗效。方法在中国知网、维普、万方、PubMed等数据库中检索关于柴胡疏肝散为主治疗乳腺增生的临床对照研究,检索时间为从建库至2020年11月,采用Jadad量表对纳入文献进行质量评定,并应用Stata 15.0软件进行Meta分析。结果最终纳入以柴胡疏肝散为主对照西药治疗乳腺增生的文献14篇,纳入柴胡疏肝散合甘麦大枣汤对照柴胡疏肝散治疗乳腺增生的文献5篇。Meta分析表明,以柴胡疏肝散为主治疗乳腺增生的临床效果高于西药(合并效应量OR=2.15,P<0.01),且柴胡疏肝散合甘麦大枣汤治疗乳腺增生的临床疗效优于柴胡疏肝散(合并效应量OR=2.16,P<0.01)。结论柴胡疏肝散合甘麦大枣汤治疗乳腺增生较以柴胡疏肝散为主的治疗及西药更具临床优势。 Objective To systematically evaluate the clinical efficacy of Chaihushugan powder in the treatment of hyperplasia of mammary glands.Methods The databases of CNKI,VIP,Wanfang,PubMed and other databases were searched for clinical controlled studies on the treatment of hyperplasia of mammary glands with Chaihushugan powder,the retrieval time was from the establishment of the database to November 2020,the included literatures were evaluated for quality,and Meta analysis was performed using Stata 15.0 software.Results This study finally resulted in 14 studies focusing on Chaihushugan powder versus western medicine in the treatment of hyperplasia of mammary glands,and 5 studies on Chaihushugan powder and Ganmaidazao decoction compared with Chaihushugan powder in the treatment of hyperplasia of mammary glands.Meta analysis showed that drugs based on Chaihushugan powder had advantages over western medicine in the treatment of breast hyperplasia(combined effect size OR=2.15,P<0.01),Chaihushugan powder and Ganmaidazao decoction had more clinical advantages than Chaihushugan powder in treating hyperplasia of mammary glands(combined effect size OR=2.16,P<0.01).Conclusion The existing studies have shown that Chaihushugan powder and Ganmaidazao decoction had more clinical advantages than drugs based on Chaihushugan powder and western medicine in treating hyperplasia of mammary glands.
作者 吴智鸿 蔡楚华 杨金玲 覃滢 WU Zhihong;CAI Chuhua;YANG Jinling;QIN Ying(不详;The Second Affiliated Hospital of Guangxi University of Science and Technology,Guangxi Zhuang Autonomous Region,Liuzhou 545006,China)
出处 《临床合理用药杂志》 2022年第19期33-36,43,共5页 Chinese Journal of Clinical Rational Drug Use
关键词 乳腺增生 乳癖 柴胡疏肝散 柴胡疏肝散合甘麦大枣汤 META分析 Hyperplasia of mammary glandsa Nodules of breast Chaihushugan powder Chaihushugan powder combined with Ganmaidazao decoction Meta analysis
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