不同程度妊娠期高血压疾病患者血清ET-1、NO、CysC水平及肾功能指标变化

Effects of the levels of serum endothelin-1,nitric oxide,and cystatin C of the pregnant women with different degrees of pregnancy-induced hypertension on their renal function

目的:分析不同程度妊娠期高血压疾病患者血清内皮素-1(ET-1)、一氧化氮(NO)和胱抑素C(CysC)变化及与肾功能指标关系。方法:选取2019年1月-2020年10月本院收治的80例妊娠期高血压疾病患者资料,根据病情程度分为妊娠期高血压30例、轻度子痫前期26例、重度子痫前期/子痫24例;根据患者是否合并肾功能损伤分为肾功能正常组46例和肾功能损伤组34例;规律产前检查健康孕妇60例为对照组。检测各组血清ET-1、NO、CysC水平,分析其与妊娠期高血压病情程度及肾功能损伤的关联性。结果:妊娠高血压疾病不同病情程度孕妇血清ET-1、CysC水平逐渐升高且均高于对照组,血清NO水平逐渐降低且均低于对照组;合并肾功能损伤孕妇血清ET-1、CysC及血肌酐(Cr)水平均高于肾功能正常孕妇,NO水平低于肾功能正常孕妇(均P<0.05)。妊娠期高血压疾病孕妇血清ET-1、CysC与Cr水平呈正相关,NO水平与Cr水平呈负相关(均P<0.05)。结论:血清ET-1、NO、CysC水平与妊娠期高血压疾病严重程度及合并肾功能损伤均具有相关性。

Objective: To investigate the change of serum endothelin-1(ET-1), nitric oxide(NO), and cystatin C(CysC) of pregnant women with different degrees of pregnancy-induced hypertension(PIH), and to study their correlated with the renal function indexes of these women. Methods: A total of 80 pregnant women with PIH were selected and were divided into group A(30 women with hypertensive disorder complicating pregnancy), group B(26 women with mild preeclampsia), and group C(24 women with severe preeclampsia/eclampsia) according to the severity of their PIH from January 2019 to October 2020. These women were also divided into group D(46 women with normal renal function) and group E(34 women with impaired renal function) according to whether accompanied with renal impairment or not. In addition, 60 healthy pregnant women who underwent regular antenatal examination were selected in control group. The levels of serum ET-1, NO, and CysC of the women in these groups were detected, and the correlation of which with the severity of PIH or renal impairment of the women was analyzed. Results: The serum ET-1 and CysC levels of the women in group A, group B, and group C had increased gradually, and which of the women in group A, group B, and group C were significantly higher than those of the women in the control group. The serum NO level of the women in group A, group B, and group C had decreased gradually, and which of the women in group A, group B, and group C was significantly lower than that of the women in the control group. The serum ET-1, CysC, and creatinine(Cr) levels of the women in group E were significantly higher than those of the women in group D, and the NO level of the women in group E was significantly lower than that of the women in group D(all P<0.05).The serum ET-1 and CysC levels of the women with PIH were positively correlated with their Cr level,and the NO level of the women with PIH was negatively correlated with their Cr level(all P<0.05).Conclusion:The serum ET-1,NO,and CysC levels of the women with PIH are related to the severity of their PIH and renal impairment.