胃肠道炎性肌纤维母细胞瘤的诊断与治疗策略

Diagnosis and treatment strategies of inflammatory myofibroblastic tumor of the gastrointes-tinal tract

胃肠道炎性肌纤维母细胞瘤(IMT)是一种临床极少见且具有低度恶性的间叶性肿瘤。它由分化的肌纤维母细胞性梭形细胞组成,常伴有大量的浆细胞、淋巴细胞及嗜酸性粒细胞等炎症细胞浸润。外科手术切除是胃肠道IMT的首选治疗方式,患者术后可获得良好预后。近年来随着影像学检查和病理学诊断技术的进步,胃肠道IMT的检出率极大提高,但其发病诱因和机制尚未完全明确,需要进一步研究证实。同时,由于胃肠道IMT缺乏规范化的诊断与治疗标准策略,导致其在临床诊断与治疗中存在漏诊或漏治。笔者回顾既往研究结果并结合团队实践经验,围绕胃肠道IMT的发病机制、临床诊断、治疗策略等方面,概述其诊断与治疗研究进展,旨在为该病的临床治疗提供参考。

Inflammatory myofibroblastic tumor(IMT)of gastrointestinal tract is a rare and low malignant mesenchymal tumor,which is composed of differentiated myofibroblastoid spindle cells and often accompanied by numerous inflammatory cells such as plasma cells,lymphocytes,and eosinophils.Surgical resection is the preferred treatment for IMT of gastrointestinal tract,and patients can achieve a good prognosis after surgery.In recent years,with the progress of imaging examination and pathological diagnosis technology,the detection rate of IMT of gastrointes-tinal tract has been greatly improved,but its pathogenesis and mechanism have not been completely investigated,requiring further research results to confirm.At the same time,due to the lack of standardized strategies for diagnosis and treatment of IMT of gastrointestinal tract,it was inevitable to miss diagnosis or treatment in clinical diagnosis and treatment.By reviewing relevant literatures and combined with the team's practical experience,the authors summarize the research progress of the diagnosis and treatment of IMT of gastrointestinal tract from the aspects of pathogenesis,clinical diagnosis and treatment strategies of IMT,aiming to provide references for the clinical treatment of surgeons.