摘要
脂蛋白脂肪酶(lipoprotein lipase,LPL)是脂质和脂蛋白代谢的关键酶。LPL主要水解富含甘油三酯脂蛋白,为代谢组织提供游离脂肪酸(free fatty acid,FFAs)。LPL是脂蛋白和细胞表面脂蛋白受体的分子桥梁,促进脂蛋白的摄取。最近研究表明,LPL在多种组织中广泛表达。大脑中LPL有多种生理功能,可以调节大脑脂质代谢、能量平衡,与阿尔兹海默症密切相关。本文主要综述LPL在神经系统最新研究进展,为神经系统相关疾病提供治疗和预防新靶点。
Lipoprotein lipase(LPL)is a key enzyme in lipid and lipoprotein metabolism.LPL mainly hydrolyzes triglyceride-rich lipoproteins and provides free fatty acid(FFAs)for metabolic tissues.LPL acts as a molecular bridge between lipoproteins and cell surface lipoprotein receptors,facilitating lipoprotein uptake.Recent studies have shown that LPL is widely expressed in tissues.LPL has a variety of physiological functions,which regulates lipid metabolism and energy balance in the brain.Besides,it is closely related to Alzheimer's disease.This paper mainly reviews the latest research progress of LPL in the nervous system and provides new targets for the treatment and prevention.
作者
吕圆
王姝之
戴斌
梁忠厚
LV Yuan;WANG Shuzhi;DAI Bin;LIANG Zhonghou(Hunan Engineering Research Center for Applied Technology of Understory Medicinal Plants,Hunan Polytechnic of Environment and Biology,Hengyang 421005,Hunan,China;University of South China,Hengyang 421001,Hunan,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2022年第9期1041-1048,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
湖南省自然科学基金(2019JJ40252,2020JJ5503)
湖南省教育厅科研项目(20K106)
湖南省发展改革委员会创新能力示范项目(湘发改投资[2021]319号)
衡阳市科技计划项目(2020021309)新冠肺炎防治基础研究专项
湖南环境生物职业技术学院青年基金项目(ZK2020-02)
衡阳市科技创新计划项目(202121034369)。
