四逆散联合小承气汤加味对功能性消化不良(肝郁气滞证)患者PG、Ghrelin和G-17水平的影响

Effect of Sini powder combined with Xiaochengqi decoction on PG, Ghrelin and G-17 levels in patients withfunctional dyspepsia (liver stagnation and Qi stagnation syndro me)

目的:探讨四逆散联合小承气汤加味对功能性消化不良(FD)(肝郁气滞证)患者临床疗效及血清胃蛋白酶原(PG)、生长激素释放肽(Ghrelin)、胃泌素17(G-17)水平的影响。方法:选取2018年3月至2020年3月建湖县中医院收治的80例FD(肝郁气滞证)患者作为观察对象。按照随机数表法将其分为两组,每组各有患者40例。对照组采用四逆散加味治疗,观察组则在此基础上联用小承气汤加味治疗。比较两组患者的治疗效果、胃动力指标、临床症状恢复情况及血清PG(包括PGⅠ、PGⅡ)、G-17、Ghrelin的水平。结果:1)观察组的临床治疗总有效率高于对照组(P<0.05)。2)治疗后,观察组血浆促肾上腺皮质激素释放激素(CRH)的水平低于对照组(P<0.05),餐前血浆瘦素(LEP)、餐后血浆LEP、血浆胃动素(MTL)的水平均高于对照组(P<0.05)。3)治疗后,观察组血清PGⅠ、PGⅡ、G-17、Ghrelin的水平均高于对照组(P<0.05)。4)治疗后,观察组上腹灼热、上腹疼痛、早饱、餐后饱胀的发生率均低于对照组(P<0.05)。结论:用四逆散联合小承气汤加味治疗FD(肝郁气滞证)的效果显著,能减轻患者的临床症状,改善其胃动力指标及血清PG、G-17、Ghrelin的水平。

Objective:To investigate the effect of Sini powder combined with Xiaochengqi decoction on the clinical efficacy and serum pepsinogen(PG),growth hormone releasing peptide(Ghrelin)and gastrin 17(G-17)levels in patients with functional dyspepsia(FD)(liver stagnation and Qi stagnation syndrome).Methods:A total of 80 patients with FD(liver stagnation and Qi stagnation syndrome)admitted to Jianhu Hospital of Traditional Chinese Medicine from March 2018 to March 2020 were selected as the observation objects.They were divided into two groups according to the random number table method,with 40 patients in each group.The control group was treated with Sini powder,and the observation group was treated with Xiaochengqi decoction on this basis.The treatment effect,gastric motility index,clinical symptom recovery and serum PG(including PGⅰ,PGⅱ),G-17 and Ghrelin levels were compared between the two groups.Results:1)The total effective rate of the observation group was higher than that of the control group(P<0.05).2)After treatment,the plasma levels of adrenocorticotropin-releasing hormone(CRH)in the observation group were lower than those in the control group(P<0.05),and the levels of preprandial plasma(leptin)LEP,postprandial plasma LEP and plasma motilin(MTL)in the observation group were higher than those in the control group(P<0.05).3)After treatment,the levels of serum PGⅰ,PGⅱ,G-17 and Ghrelin in the observation group were higher than those in the control group(P<0.05).4)After treatment,the incidence of epigastric burn,epigastric pain,early satiety and postprandial fullness in the observation group were lower than those in the control group(P<0.05).Conclusion:Sini powder combined with Xiaochengqi decoction has significant effect in the treatment of FD(liver stagnation and Qi stagnation syndrome),which can reduce the clinical symptoms,improve the gastric motility index and serum PG,G-17,Ghrelin levels.